TY - JOUR
T1 - Targeting RNA-binding proteins in acute and chronic leukemia
AU - Elcheva, Irina A.
AU - Spiegelman, Vladimir S.
N1 - Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2021/2
Y1 - 2021/2
N2 - RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.
AB - RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.
UR - http://www.scopus.com/inward/record.url?scp=85094953028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094953028&partnerID=8YFLogxK
U2 - 10.1038/s41375-020-01066-4
DO - 10.1038/s41375-020-01066-4
M3 - Article
C2 - 33149266
AN - SCOPUS:85094953028
SN - 0887-6924
VL - 35
SP - 360
EP - 376
JO - Leukemia
JF - Leukemia
IS - 2
ER -