T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome

Barbara A. Miller, Michael M. Reid, Marilyn Nell, Jeffrey M. Lipton, Stephen E. Sallan, David G. Nathan, Ramana Tantravahi

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Summary A case of childhood T‐cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p). Cytogenetic studies at relapse showed, in addition to 9p, a partial deletion of the long arm of one chromosome 6 (6q) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T‐cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalBritish Journal of Haematology
Issue number1
StatePublished - Jan 1984

All Science Journal Classification (ASJC) codes

  • Hematology


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