TY - JOUR
T1 - Tea and coffee consumption and risk of colon and rectal cancer in middle-aged finnish men
AU - Hartman, Terryl J.
AU - Tangrea, Joseph A.
AU - Pietinen, Pirjo
AU - Malila, Nea
AU - Virtanen, Mikko
AU - Taylor, Philip R.
AU - Albanes, Demetrius
N1 - Funding Information:
This work was supported by Public Health Service Contract N01-CN-45165 from the National Cancer Institute, National Institutes of Health, US Department of Health and Human Services. Address reprint requests to Terry Hartman, National Cancer Institute, 6006 Executive Blvd., Suite 321, MSC 7058, Bethesda, MD 20892-7326. FAX: (301) 435-8645. E-mail: th86d<§nih.gov.
PY - 1998
Y1 - 1998
N2 - The association between coffee and black tea consumption and the subsequent risk of colon and rectal cancer was investigated within a Finnish clinical trial cohort. One hundred eleven cases of colon cancer and 83 cases of rectal cancer were diagnosed over a median of 8.0 years of follow-up. Proportional hazards regression models were used to derive adjusted relative risks (RR) and 95% confidence intervals (CI) for the association between coffee and tea consumption and cancer incidence. After controlling for confounders, coffee was not significantly associated with colon or rectal cancer. A positive association was seen for increased consumption of tea drinking and colon cancer. Compared with persons who did not drink tea, those who consumed <1 cup/day had an RR of 1.40 (95% CI = 0.84-2.33) and those who consumed ≤1 cup/day had an RR of 2.09 (95% CI = 1.34-3.26, p for trend = 0.001). In contrast, tea consumption had little effect on rectal cancer incidence. This study does not support the hypothesis that coffee and tea protect against colorectal cancer risk. However, given the strength of the tea-colon cancer association and the significant gradient of risk we observed across level of intake, further epidemiologic research of this relationship in other populations seems warranted.
AB - The association between coffee and black tea consumption and the subsequent risk of colon and rectal cancer was investigated within a Finnish clinical trial cohort. One hundred eleven cases of colon cancer and 83 cases of rectal cancer were diagnosed over a median of 8.0 years of follow-up. Proportional hazards regression models were used to derive adjusted relative risks (RR) and 95% confidence intervals (CI) for the association between coffee and tea consumption and cancer incidence. After controlling for confounders, coffee was not significantly associated with colon or rectal cancer. A positive association was seen for increased consumption of tea drinking and colon cancer. Compared with persons who did not drink tea, those who consumed <1 cup/day had an RR of 1.40 (95% CI = 0.84-2.33) and those who consumed ≤1 cup/day had an RR of 2.09 (95% CI = 1.34-3.26, p for trend = 0.001). In contrast, tea consumption had little effect on rectal cancer incidence. This study does not support the hypothesis that coffee and tea protect against colorectal cancer risk. However, given the strength of the tea-colon cancer association and the significant gradient of risk we observed across level of intake, further epidemiologic research of this relationship in other populations seems warranted.
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U2 - 10.1080/01635589809514676
DO - 10.1080/01635589809514676
M3 - Article
C2 - 9682247
AN - SCOPUS:0031867206
SN - 0163-5581
VL - 31
SP - 41
EP - 48
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 1
ER -