TY - JOUR
T1 - Tea, or tea and milk, inhibit mammary gland and colon carcinogenesis in rats
AU - Weisburger, John H.
AU - Rivenson, Abraham
AU - Garr, Kathy
AU - Aliaga, Cesar
N1 - Funding Information:
Parts of this work was presented at the annual meeting of the American Association for Cancer Research. on April 21, 1996 in Washington, DC and at the Food and Cancer Prevention II Conference on May 20. 1996 in Ede, the Netherlands. I am indebted to Uni-lever and Lipton Research for providing travel funds to attend the Ede Conference. Grant or contract support for our research from the Tea Trade Health Research Association, the National Cancer Institute. and gifts from the Texaco Foundation and the Friends Against Cancer Team are much appreciated. Ms. Beth-Alayne McKinney and Ms. Maris Tune were excellent editorial assistants. We are also indebted to Dr. Zeno Apostolides, Department of Biochemistry, University of Pretoria, South Africa, for discussions and information.
PY - 1997/3/19
Y1 - 1997/3/19
N2 - Research was performed on the effect of tea, or tea and milk, instead of drinking water, in rat models of cancer in the mammary gland or colon. Solutions of 1.25% (w/v) black tea, or 1.85% (v/v) milk in tea were prepared three times per week. SD rats were given tea beginning at 42 days of age; one group was gavaged 5 mg 7,12-dimethylbenz[a]anthracene (DMBA) at 49 days of age; another group received 8.4 mg 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) twice per week beginning at age 49, then 14 mg twice a week for 4 weeks more. The groups on DMBA were killed 33 weeks later, and those on IQ 39 weeks later. Tea decreased the mammary gland tumor multiplicity and volume, and milk and tea had a greater protective action. Male F344 rats were given two doses of 15 mg/kg azoxymethane (AOM) on weeks 6 and 7, and some groups started on tea, or tea and milk at 5 weeks; one group started on tea 2 days after AOM. Foci of aberrant crypts in the colon were decreased, after 9 weeks, in the groups on tea, or tea and milk during AOM administration, but not after AOM. Thus, tea decreases mammary tumor induction, and the production of foci of aberrant crypts in the colon. Milk potentiates these inhibiting effects.
AB - Research was performed on the effect of tea, or tea and milk, instead of drinking water, in rat models of cancer in the mammary gland or colon. Solutions of 1.25% (w/v) black tea, or 1.85% (v/v) milk in tea were prepared three times per week. SD rats were given tea beginning at 42 days of age; one group was gavaged 5 mg 7,12-dimethylbenz[a]anthracene (DMBA) at 49 days of age; another group received 8.4 mg 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) twice per week beginning at age 49, then 14 mg twice a week for 4 weeks more. The groups on DMBA were killed 33 weeks later, and those on IQ 39 weeks later. Tea decreased the mammary gland tumor multiplicity and volume, and milk and tea had a greater protective action. Male F344 rats were given two doses of 15 mg/kg azoxymethane (AOM) on weeks 6 and 7, and some groups started on tea, or tea and milk at 5 weeks; one group started on tea 2 days after AOM. Foci of aberrant crypts in the colon were decreased, after 9 weeks, in the groups on tea, or tea and milk during AOM administration, but not after AOM. Thus, tea decreases mammary tumor induction, and the production of foci of aberrant crypts in the colon. Milk potentiates these inhibiting effects.
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U2 - 10.1016/S0304-3835(97)04693-4
DO - 10.1016/S0304-3835(97)04693-4
M3 - Article
C2 - 9103322
AN - SCOPUS:0030942890
SN - 0304-3835
VL - 114
SP - 323
EP - 327
JO - Cancer Letters
JF - Cancer Letters
IS - 1-2
ER -
