Telomere dysfunction in Tert knockout mice delays Braf^V600E-induced melanoma development

Keyphrases

• Knock-in Mouse Model 100%
• Tert 100%
• BRAF V600E 100%
• Melanoma Growth 100%
• Telomere Dysfunction 100%
• Melanomagenesis 100%
• Tumor 50%
• Ultraviolet Radiation 50%
• C57BL 25%
• Mitogen-activated Protein Kinase 25%
• Mouse Model 25%
• Cell-derived 25%
• Tumor Cells 25%
• Melanoma Treatment 25%
• Radiation Effects 25%
• Telomere 25%
• Genomic Instability 25%
• Ultraviolet-B (UV-B) 25%
• DNA Damage 25%
• Induced mutagenesis 25%
• Chromosomal Rearrangements 25%
• Induced mutation 25%
• BRAF V600E mutation 25%
• Ultraviolet Exposure 25%
• P53 Protein Expression 25%
• Telomerase Activity 25%
• TERT Promoter 25%
• Mutant p53 Protein 25%
• Telomerase Gene 25%
• Telomere Crisis 25%
• Cultured Tumor Cells 25%
• Short Telomeres 25%
• UVB-induced 25%
• Chromosomal Fusion 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein P53 100%
• Knockout Mouse 100%
• Melanoma 100%
• Ultraviolet Radiation 100%
• Neoplasm 66%
• Telomerase 66%
• Mitogen Activated Protein Kinase 33%
• Mouse Model 33%
• Mutagenesis 33%
• Radiation Exposure 33%

Biochemistry, Genetics and Molecular Biology

• Knockout Mouse 100%
• Telomere 100%
• P53 42%
• Ultraviolet Radiation 42%
• Telomerase 28%
• Protein Expression 14%
• Wild Type 14%
• Promoter Region 14%
• Transcription 14%
• Mitogen-Activated Protein Kinase 14%
• Mutagenesis 14%
• Genome Instability 14%
• DNA Damage 14%
• Mouse Model 14%
• Induced Mutation 14%
• Staining 14%
• Tumor Cell Culture 14%