Telomere length and risk of Parkinson's disease

Hao Wang; Honglei Chen; Xiang Gao; Monica McGrath; Dwayne Deer; Immaculata De Vivo; Michael A. Schwarzschild; Alberto Ascherio

doi:10.1002/mds.21867

Telomere length and risk of Parkinson's disease

Hao Wang, Honglei Chen, Xiang Gao, Monica McGrath, Dwayne Deer, Immaculata De Vivo, Michael A. Schwarzschild, Alberto Ascherio

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.

Original language	English (US)
Pages (from-to)	302-305
Number of pages	4
Journal	Movement Disorders
Volume	23
Issue number	2
DOIs	https://doi.org/10.1002/mds.21867
State	Published - Jan 30 2008

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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abstract = "We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.",

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AU - Wang, Hao

AU - Chen, Honglei

AU - Gao, Xiang

AU - McGrath, Monica

AU - Deer, Dwayne

AU - De Vivo, Immaculata

AU - Schwarzschild, Michael A.

AU - Ascherio, Alberto

PY - 2008/1/30

Y1 - 2008/1/30

N2 - We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.

AB - We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.

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Telomere length and risk of Parkinson's disease

Abstract

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