TY - JOUR
T1 - Temporal specification and bilaterality of human neocortical topographic gene expression
AU - Pletikos, Mihovil
AU - Sousa, André M.M.
AU - Sedmak, Goran
AU - Meyer, Kyle A.
AU - Zhu, Ying
AU - Cheng, Feng
AU - Li, Mingfeng
AU - Kawasawa, Yuka Imamura
AU - Šestan, Nenad
N1 - Funding Information:
We thank M. Horn for helping with processing macaque tissue, Xuming Xu for help with data analyses, and the members of the Šestan laboratory for valuable comments. Human postmortem tissue was obtained from sources listed in the Supplemental Information . Support for predoctoral fellowships was provided by the Portuguese Foundation for Science and Technology (A.M.M.S.), the Croatian Science Foundation (09.01/414; G.S.), the National Science Foundation (DGE-1122492; K.A.M.), and the China Scholarship Council (Y.Z.). This work was supported by grants from the NIH (MH081896, MH089929, NS051869), the Kavli Foundation, NARSAD, the Foster-Davis Foundation, and by a James S. McDonnell Foundation Scholar Award (N.Š.).
PY - 2014/1/22
Y1 - 2014/1/22
N2 - Transcriptional events involved in the development of human cerebral neocortex are poorly understood. Here, we analyzed the temporal dynamics and laterality of gene expression in human and macaque monkey neocortex. We found that interareal differences exhibit a temporal hourglass pattern, dividing the human neocortical development into three major phases. The first phase, corresponding to prenatal development, is characterized by the highest number of differential expressed genes among areas and gradient-like expression patterns, including those that are different between human and macaque. The second, preadolescent phase, is characterized by lesser interareal expression differences and by an increased synchronization of areal transcriptomes. During the third phase, from adolescence onward, differential expression among areas increases again driven predominantly by a subset of areas, without obvious gradient-like patterns. Analyses of left-right gene expression revealed population-level global symmetry throughout the fetal and postnatal time span. Thus, human neocortical topographic gene expression is temporally specified and globally symmetric.
AB - Transcriptional events involved in the development of human cerebral neocortex are poorly understood. Here, we analyzed the temporal dynamics and laterality of gene expression in human and macaque monkey neocortex. We found that interareal differences exhibit a temporal hourglass pattern, dividing the human neocortical development into three major phases. The first phase, corresponding to prenatal development, is characterized by the highest number of differential expressed genes among areas and gradient-like expression patterns, including those that are different between human and macaque. The second, preadolescent phase, is characterized by lesser interareal expression differences and by an increased synchronization of areal transcriptomes. During the third phase, from adolescence onward, differential expression among areas increases again driven predominantly by a subset of areas, without obvious gradient-like patterns. Analyses of left-right gene expression revealed population-level global symmetry throughout the fetal and postnatal time span. Thus, human neocortical topographic gene expression is temporally specified and globally symmetric.
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U2 - 10.1016/j.neuron.2013.11.018
DO - 10.1016/j.neuron.2013.11.018
M3 - Article
C2 - 24373884
AN - SCOPUS:84892772773
SN - 0896-6273
VL - 81
SP - 321
EP - 332
JO - Neuron
JF - Neuron
IS - 2
ER -