Ten Cases of Primary Mediastinal Malignant Germ Cell Tumor

Takefumi Komiya, Minoru Takada, Takasi Yana, Kaoru Matsui, Noriyuki Masuda, Yoko Kusunoki, Yahiro Kotake, Tsutomu Yasumitsu, Hideo Morino, Masaki Kikui

Research output: Contribution to journalArticlepeer-review


Ten cases of primary mediastinal malignant germ cell tumors were studied retrospectively. All but one were male and most of the patients suffered from chest pain or cough. While 3 patients who were classified as seminoma had normal serum tumor markers, seven non-seminomas had high levels of α-fetoprotein (AFP) or carcinoembryonic antigen (CEA). Of the 5 patients who initially received cisplatin-based combination chemotherapy, 3 attained a pathological complete response (CR) by thoracotomy. Of the 5 patients whose tumors were initially resected, 4 received adjuvant cisplatin-containing chemotherapy. In summary 7 of the 9 remain alive and disease-free. These results strongly suggest that combined modality treatment provides good results for patients with primary mediastinal malignant germ cell tumor.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalJapanese Journal of Lung Cancer
Issue number4
StatePublished - 1995

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine


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