@article{38a73053e24e4e4993e6958df4438739,
title = "Test-retest reliability of peripheral arterial tonometry in the metabolic syndrome",
abstract = "Endothelial dysfunction is an important contributor to atherosclerosis and cardiovascular disease. However, routine assessment via angiography or flow-mediated dilation is difficult due to technical limitations. Peripheral arterial tonometry (PAT) is a promising alternative method for non-invasive assessment of endothelial dysfunction. This study assessed the test-retest reliability of PAT in adults with the metabolic syndrome (n = 20) and provides sample size and power estimates for study design. Participants completed five PAT tests each separated by 1 week. The PAT-derived reactive hyperaemia index (RHI) showed robust repeatability (intra-class correlation = 0.74). A parallel-arm study powered at 0.90 would require 22 participants to detect an absolute change in RHI of 0.40 units (equal to ∼25% change in this sample), whereas a crossover study would require 12 participants. In conclusion, we have demonstrated that PAT can be used to assess endothelial dysfunction in adults with the metabolic syndrome as reliably as in healthy samples.",
author = "Sauder, {Katherine A.} and West, {Sheila G.} and McCrea, {Cindy E.} and Campbell, {Janice M.} and Jenkins, {Alexandra L.} and Jenkins, {David J.A.} and Kendall, {Cyril W.C.}",
note = "Funding Information: KAS, CEM and SGW have received travel funding and research funding from the American Pistachio Growers. ALJ is a director of Glycemic Index Laboratories, Toronto, Ontario, Canada. JC is employed by Glycemic Index Laboratories. DJAJ reported serving on the Scientific Advisory Board of Unilever, Sanitarium Company, California Strawberry Commission, Loblaw Supermarket, Herbal Life International, Nutritional Fundamental for Health, Pacific Health Laboratories, Metagenics, Bayer Consumer Care, Orafti, Dean Foods, Kellogg{\textquoteright}s, Quaker Oats, Procter and Gamble, Coca-Cola, NuVal Griffin Hospital, Abbott, Pulse Canada, Saskatchewan Pulse Growers and Canola Council of Canada; receiving honoraria for scientific advice from the Almond Board of California, International Tree Nut Council Nutrition Research and Education Foundation, Barilla, Unilever Canada, Solae, Oldways, Kellogg{\textquoteright}s, Quaker Oats, Procter and Gamble, Coca-Cola, NuVal Griffin Hospital, Abbott, Canola Council of Canada, Dean Foods, California Strawberry Commission, Haine Celestial and Alpro Foundation; being on the speakers panel for the Almond Board of California; receiving research grants from Loblaw Brands Ltd, Unilever, Barilla, Almond Board of California, Solae, Haine Celestial, Sanitarium Company, Orafti, International Tree Nut Council and Peanut Institute; and receiving travel support to meetings from the Almond Board of California, Unilever, Alpro Foundation and International Tree Nut Council. CWCK has received research grants, travel funding, consultant fees, honoraria or has served on the scientific advisory board for Abbott, Advanced Food Materials Network, Almond Board of California, American Peanut Council, American Pistachio Growers, Barilla, California Strawberry Commission, Canadian Institutes of Health Research, Canola Council of Canada, Danone, General Mills, Hain Celestial, International Tree Nut Council, Kellogg, Loblaw Brands Ltd, Oldways, Orafti, Paramount Farms, Pulse Canada, Saskatchewan Pulse Growers, Solae and Unilever. Funding Information: This work was supported by a grant from American Pistachio Growers (Fresno, CA, USA) and, in part, by grant F31AG043224 (KAS) from the National Institutes of Health (Bethesda, MD, USA).",
year = "2014",
month = may,
doi = "10.1177/1479164114525971",
language = "English (US)",
volume = "11",
pages = "201--207",
journal = "Diabetes and Vascular Disease Research",
issn = "1479-1641",
publisher = "SAGE Publications Ltd",
number = "3",
}
