TY - JOUR
T1 - Testicular Ischemia Due to Intravascular Large B-Cell Lymphoma
T2 - A Novel Presentation in an Immunosuppressed Individual
AU - Tranchida, Paul
AU - Bayerl, Michael
AU - Voelpel, Mary Jo
AU - Palutke, Margarita
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2003/10
Y1 - 2003/10
N2 - A 56-year-old man presented with fever, disorientation, and testicular pain. He was receiving azathioprine immunosuppression for autoimmune hepatitis. Orchiectomy identified occlusion of spermatic cord vessels by intravascular large B-cell lymphoma (IVLBL) and ischemic changes in the testis. Tumor cells were positive for CD 10, CD 20, CD 30, and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) and early region RNA (EBER). He was treated with the cessation of azathioprine, chemotherapy, anti-CD 20 immunotherapy, and radiotherapy. Twenty months after diagnosis, he is alive with no evidence of lymphoma or hepatitis. This is the first report of IVLBL presenting with testicular ischemia. It highlights the importance of prompt diagnosis and intervention to achieve durable response. That this lymphoma arose in the setting of immunosuppressive therapy introduces additional complexity relating to pathogenesis, clinical behavior, and treatment.
AB - A 56-year-old man presented with fever, disorientation, and testicular pain. He was receiving azathioprine immunosuppression for autoimmune hepatitis. Orchiectomy identified occlusion of spermatic cord vessels by intravascular large B-cell lymphoma (IVLBL) and ischemic changes in the testis. Tumor cells were positive for CD 10, CD 20, CD 30, and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) and early region RNA (EBER). He was treated with the cessation of azathioprine, chemotherapy, anti-CD 20 immunotherapy, and radiotherapy. Twenty months after diagnosis, he is alive with no evidence of lymphoma or hepatitis. This is the first report of IVLBL presenting with testicular ischemia. It highlights the importance of prompt diagnosis and intervention to achieve durable response. That this lymphoma arose in the setting of immunosuppressive therapy introduces additional complexity relating to pathogenesis, clinical behavior, and treatment.
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U2 - 10.1177/106689690301100414
DO - 10.1177/106689690301100414
M3 - Article
C2 - 14615832
AN - SCOPUS:0242469096
SN - 1066-8969
VL - 11
SP - 319
EP - 324
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 4
ER -
