TY - JOUR
T1 - Tetrahedron DNA dendrimers and their encapsulation of gold nanoparticles
AU - Zhou, Tao
AU - Wang, Yijie
AU - Dong, Yuanchen
AU - Chen, Chun
AU - Liu, Dongsheng
AU - Yang, Zhongqiang
N1 - Funding Information:
We thank the National Natural Science Foundation of China ( 21174077 , 91027046 , 21121004 ), the National Basic Research Program of China ( 2013CB932803 ) and Beijing Municipal Science & Technology Commission for financial support.
PY - 2014/8/15
Y1 - 2014/8/15
N2 - DNA dendrimers have achieved increasing attention recently. Previously reported DNA dendrimers used Y-DNA as monomers. Tetrahedron DNA is a rigid tetrahedral cage made of DNA. Herein, we use tetrahedron DNA as monomers to prepare tetrahedron DNA dendrimers. The prepared tetrahedron DNA dendrimers have larger size compared with those made of Y-DNA. In addition, thanks to the central cavity of tetrahedron DNA monomers, some nanoscale structures (e.g., gold nanoparticles) can be encapsulated within tetrahedron DNA monomers. Tetrahedron DNA encapsulated with gold nanoparticles can be further assembled into dendrimers, guiding gold nanoparticles into clusters.
AB - DNA dendrimers have achieved increasing attention recently. Previously reported DNA dendrimers used Y-DNA as monomers. Tetrahedron DNA is a rigid tetrahedral cage made of DNA. Herein, we use tetrahedron DNA as monomers to prepare tetrahedron DNA dendrimers. The prepared tetrahedron DNA dendrimers have larger size compared with those made of Y-DNA. In addition, thanks to the central cavity of tetrahedron DNA monomers, some nanoscale structures (e.g., gold nanoparticles) can be encapsulated within tetrahedron DNA monomers. Tetrahedron DNA encapsulated with gold nanoparticles can be further assembled into dendrimers, guiding gold nanoparticles into clusters.
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U2 - 10.1016/j.bmc.2014.05.062
DO - 10.1016/j.bmc.2014.05.062
M3 - Article
C2 - 24953949
AN - SCOPUS:84906265109
SN - 0968-0896
VL - 22
SP - 4391
EP - 4394
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 16
ER -