TY - JOUR
T1 - TGF-β
T2 - Its role in the differentiation and function of T regulatory and effector cells
AU - Yang, Sujuan
AU - Zheng, Songguo
N1 - Funding Information:
This work was supported in part by the Natural Science Foundation of Guangdong Province (Grant No. 2014A030308005), and grants from the Department of Science and Technology in Guangzhou City and from the Department of Science and Technology in Guangdong Province. This work was supported in party by the National
Publisher Copyright:
© TUBİTAK.
PY - 2017
Y1 - 2017
N2 - The cytokine transforming growth factor-β (TGF-β) plays an important role in the maintenance of T cell homeostasis, immune tolerance to self-antigens, and T cell differentiation during immune responses. TGF-β has pleiotropic effects on adaptive immune responses, especially on the differentiation of T helper and T regulatory cell populations, which depends on the T cell differentiation status and the stimulation conditions. This review provides an update about the roles of TGF-β in T cell responses, especially in the regulation of Treg development and biological features under steady state and inflammation. We also discuss the additional roles that TGF-β plays in the development and function of other T helper cells, such as Th1, Th2, Th9, Th17, and Th22 cells during inflammation.
AB - The cytokine transforming growth factor-β (TGF-β) plays an important role in the maintenance of T cell homeostasis, immune tolerance to self-antigens, and T cell differentiation during immune responses. TGF-β has pleiotropic effects on adaptive immune responses, especially on the differentiation of T helper and T regulatory cell populations, which depends on the T cell differentiation status and the stimulation conditions. This review provides an update about the roles of TGF-β in T cell responses, especially in the regulation of Treg development and biological features under steady state and inflammation. We also discuss the additional roles that TGF-β plays in the development and function of other T helper cells, such as Th1, Th2, Th9, Th17, and Th22 cells during inflammation.
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U2 - 10.3906/biy-1604-6
DO - 10.3906/biy-1604-6
M3 - Review article
AN - SCOPUS:85032441075
SN - 1300-0152
VL - 41
JO - Turkish Journal of Biology
JF - Turkish Journal of Biology
IS - 1
ER -