TY - JOUR
T1 - Th1 immune response takeover among patients with severe Japanese encephalitis infection
AU - Pujhari, Sujit Kumar
AU - Prabhakar, Sudesh
AU - Ratho, Radhakanta
AU - Mishra, Baijayantimala
AU - Modi, Manish
AU - Sharma, Sandeep
AU - Singh, Paramjeet
N1 - Funding Information:
The work is partially funded by a grant from Indian Council of Medical Research, New Delhi to support this study.
PY - 2013/10/15
Y1 - 2013/10/15
N2 - The present study was intended to explore the dynamics of viral and host factors determining the outcome of Japanese encephalitis viral infection. 223 patients with acute encephalitic syndrome, 126 with febrile illness suspected of JE and 79 apparently healthy individuals as control were enrolled. Elevated levels of TNF-α and IL-6 in encephalitis patients and IFN-γ in febrile JE patients without encephalitis were observed. A cutoff value of > 55. pg/ml of TNF-α and > 370. pg/ml of IL-6 in CSF was found as poor prognostic marker. Th1 shift (IFN-γ/IL-4: > 1) was observed in encephalitis patients.
AB - The present study was intended to explore the dynamics of viral and host factors determining the outcome of Japanese encephalitis viral infection. 223 patients with acute encephalitic syndrome, 126 with febrile illness suspected of JE and 79 apparently healthy individuals as control were enrolled. Elevated levels of TNF-α and IL-6 in encephalitis patients and IFN-γ in febrile JE patients without encephalitis were observed. A cutoff value of > 55. pg/ml of TNF-α and > 370. pg/ml of IL-6 in CSF was found as poor prognostic marker. Th1 shift (IFN-γ/IL-4: > 1) was observed in encephalitis patients.
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U2 - 10.1016/j.jneuroim.2013.08.003
DO - 10.1016/j.jneuroim.2013.08.003
M3 - Article
C2 - 23993655
AN - SCOPUS:84884819140
SN - 0165-5728
VL - 263
SP - 133
EP - 138
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -