The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design

Ruth E. Patterson, Graham A. Colditz, Frank B. Hu, Kathryn H. Schmitz, Rexford S. Ahima, Ross C. Brownson, Kenneth R. Carson, Jorge E. Chavarro, Lewis A. Chodosh, Sarah Gehlert, Jeff Gill, Karen Glanz, Debra Haire-Joshu, Karen Louise Herbst, Christine M. Hoehner, Peter S. Hovmand, Melinda L. Irwin, Linda A. Jacobs, Aimee S. James, Lee W. JonesJacqueline Kerr, Adam S. Kibel, Irena B. King, Jennifer A. Ligibel, Jeffrey A. Meyerhardt, Loki Natarajan, Marian L. Neuhouser, Jerrold M. Olefsky, Enola K. Proctor, Susan Redline, Cheryl L. Rock, Bernard Rosner, David B. Sarwer, J. Sanford Schwartz, Dorothy D. Sears, Howard D. Sesso, Meir J. Stampfer, S. V. Subramanian, Elsie M. Taveras, Julia Tchou, Beti Thompson, Andrea B. Troxel, Marianne Wessling-Resnick, Kathleen Y. Wolin, Mark D. Thornquist

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Purpose: Recognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms. Methods: The National Cancer Institute developed an innovative concept to establish a center grant mechanism in nutrition, energetics, and physical activity, referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011-2016 TREC Collaborative Network and the 15 research projects being conducted at the centers. Results: Four academic institutions were awarded TREC center grants in 2011: Harvard University, University of California San Diego, University of Pennsylvania, and Washington University in St. Louis. The Fred Hutchinson Cancer Research Center is the Coordination Center. The TREC research portfolio includes three animal studies, three cohort studies, four randomized clinical trials, one cross-sectional study, and two modeling studies. Disciplines represented by TREC investigators include basic science, endocrinology, epidemiology, biostatistics, behavior, medicine, nutrition, physical activity, genetics, engineering, health economics, and computer science. Approximately 41,000 participants will be involved in these studies, including children, healthy adults, and breast and prostate cancer survivors. Outcomes include biomarkers of cancer risk, changes in weight and physical activity, persistent adverse treatment effects (e.g., lymphedema, urinary and sexual function), and breast and prostate cancer mortality. Conclusion: The NIH Science of Team Science group will evaluate the value added by this collaborative science. However, the most important outcome will be whether this transdisciplinary initiative improves the health of Americans at risk of cancer as well as cancer survivors.

Original languageEnglish (US)
Pages (from-to)695-704
Number of pages10
JournalCancer Causes and Control
Issue number4
StatePublished - Apr 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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