The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies

Donald G. Patterson; Wayman E. Turner; Louis R. Alexander; Sandra Isaacs; Larry L. Needham

doi:10.1016/0045-6535(89)90212-9

The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies

Donald G. Patterson, Wayman E. Turner, Louis R. Alexander, Sandra Isaacs, Larry L. Needham

Forensic Science Program

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We present the changes to our published serum TCDD method including: 1) lower amount of serum required (100 g) for normal concentration levels to be measured; 2) addition of an external standard which allows for each analysis the calculation of internal standard recovery, the isomer specificity, and 10,000 RP at the time of peak detection; 3) more stringent QC requirements for a valid TCDD result; and 4) additional measures to protect against carryover from sample-to-sample. We also present a method validation and performance evaluation, along with QC results and ranges of concentration values that we determined in over 1,000 serum samples from Agent Orange, Ranch Hand, and NIOSH Worker Studies.

Original language	English (US)
Pages (from-to)	875-882
Number of pages	8
Journal	Chemosphere
Volume	18
Issue number	1-6
DOIs	https://doi.org/10.1016/0045-6535(89)90212-9
State	Published - 1989

All Science Journal Classification (ASJC) codes

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Health, Toxicology and Mutagenesis

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Patterson, D. G., Turner, W. E., Alexander, L. R., Isaacs, S., & Needham, L. L. (1989). The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies. Chemosphere, 18(1-6), 875-882. https://doi.org/10.1016/0045-6535(89)90212-9

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title = "The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies",

abstract = "We present the changes to our published serum TCDD method including: 1) lower amount of serum required (100 g) for normal concentration levels to be measured; 2) addition of an external standard which allows for each analysis the calculation of internal standard recovery, the isomer specificity, and 10,000 RP at the time of peak detection; 3) more stringent QC requirements for a valid TCDD result; and 4) additional measures to protect against carryover from sample-to-sample. We also present a method validation and performance evaluation, along with QC results and ranges of concentration values that we determined in over 1,000 serum samples from Agent Orange, Ranch Hand, and NIOSH Worker Studies.",

author = "Patterson, {Donald G.} and Turner, {Wayman E.} and Alexander, {Louis R.} and Sandra Isaacs and Needham, {Larry L.}",

year = "1989",

doi = "10.1016/0045-6535(89)90212-9",

language = "English (US)",

volume = "18",

pages = "875--882",

journal = "Chemosphere",

issn = "0045-6535",

publisher = "Elsevier Ltd",

number = "1-6",

}

Patterson, DG, Turner, WE, Alexander, LR, Isaacs, S & Needham, LL 1989, 'The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies', Chemosphere, vol. 18, no. 1-6, pp. 875-882. https://doi.org/10.1016/0045-6535(89)90212-9

The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies. / Patterson, Donald G.; Turner, Wayman E.; Alexander, Louis R. et al.
In: Chemosphere, Vol. 18, No. 1-6, 1989, p. 875-882.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies

AU - Patterson, Donald G.

AU - Turner, Wayman E.

AU - Alexander, Louis R.

AU - Isaacs, Sandra

AU - Needham, Larry L.

PY - 1989

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N2 - We present the changes to our published serum TCDD method including: 1) lower amount of serum required (100 g) for normal concentration levels to be measured; 2) addition of an external standard which allows for each analysis the calculation of internal standard recovery, the isomer specificity, and 10,000 RP at the time of peak detection; 3) more stringent QC requirements for a valid TCDD result; and 4) additional measures to protect against carryover from sample-to-sample. We also present a method validation and performance evaluation, along with QC results and ranges of concentration values that we determined in over 1,000 serum samples from Agent Orange, Ranch Hand, and NIOSH Worker Studies.

AB - We present the changes to our published serum TCDD method including: 1) lower amount of serum required (100 g) for normal concentration levels to be measured; 2) addition of an external standard which allows for each analysis the calculation of internal standard recovery, the isomer specificity, and 10,000 RP at the time of peak detection; 3) more stringent QC requirements for a valid TCDD result; and 4) additional measures to protect against carryover from sample-to-sample. We also present a method validation and performance evaluation, along with QC results and ranges of concentration values that we determined in over 1,000 serum samples from Agent Orange, Ranch Hand, and NIOSH Worker Studies.

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The analytical methodology and method performance for the determination of 2,3,7,8-TCDD in serum for the Vietnam Veteran Agent Orange validation study, the ranch hand validation and half-life studies, and selected Niosh worker studies

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