Abstract
Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1231-1238 |
| Number of pages | 8 |
| Journal | Development |
| Volume | 128 |
| Issue number | 8 |
| State | Published - 2001 |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Developmental Biology