TY - JOUR
T1 - The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies
AU - Vecchione, Rachel
AU - Vigna, Chelsea
AU - Whitman, Casey
AU - Kauffman, Elizabeth M.
AU - Braun, Joseph M.
AU - Chen, Aimin
AU - Xu, Yingying
AU - Hamra, Ghassan B.
AU - Lanphear, Bruce P.
AU - Yolton, Kimberly
AU - Croen, Lisa A.
AU - Fallin, M. Daniele
AU - Irva Hertz-Picciotto, Hertz-Picciotto
AU - Newschaffer, Craig J.
AU - Lyall, Kristen
N1 - Funding Information:
This work was supported by: NIH Grant 1R01ES026903-01A1 (PI: Newschaffer). Primary data collection for HOME was funded by P01 ES011261, R01 ES14575, and R01 ES020349. The EARLI Study was funded by the National Institute of Environmental Health Sciences, the National Institute of Mental Health, the National Institute of Child Health and Human Development, and the National Institute of Neurologic Disease and Stroke (R01 ES016443) with additional funding from Autism Speaks (AS 5938). JMB’s institution was financially compensated for his services as an expert witness for plaintiffs in litigation related to PFAS-contaminated drinking water; these funds were not paid to JMB directly. JMB was financially compensated for serving as an expert witness for plaintiffs in litigation related to secondhand tobacco smoke exposure and received an honorarium for serving on an advisory panel to Quest Diagnostics.
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/2
Y1 - 2021/2
N2 - We examined the association between prenatal fish intake and child autism-related traits according to Social Responsiveness Scale (SRS) and cognitive development scores in two US prospective pregnancy cohorts. In adjusted linear regression analyses, higher maternal fish intake in the second half of pregnancy was associated with increased child autism traits (higher raw SRS scores; ß = 5.60, 95%CI 1.76, 12.97). Differences by fish type were suggested; shellfish and large fish species were associated with increases, and salmon with decreases, in child SRS scores. Clear patterns with cognitive scores in the two cohorts were not observed. Future work should further evaluate potential critical windows of prenatal fish intake, and the role of different fish types in association with child autism-related outcomes.
AB - We examined the association between prenatal fish intake and child autism-related traits according to Social Responsiveness Scale (SRS) and cognitive development scores in two US prospective pregnancy cohorts. In adjusted linear regression analyses, higher maternal fish intake in the second half of pregnancy was associated with increased child autism traits (higher raw SRS scores; ß = 5.60, 95%CI 1.76, 12.97). Differences by fish type were suggested; shellfish and large fish species were associated with increases, and salmon with decreases, in child SRS scores. Clear patterns with cognitive scores in the two cohorts were not observed. Future work should further evaluate potential critical windows of prenatal fish intake, and the role of different fish types in association with child autism-related outcomes.
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U2 - 10.1007/s10803-020-04546-9
DO - 10.1007/s10803-020-04546-9
M3 - Article
C2 - 32519188
AN - SCOPUS:85086157231
SN - 0162-3257
VL - 51
SP - 487
EP - 500
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 2
ER -