TY - JOUR
T1 - The association between restless legs syndrome and premotor symptoms of Parkinson's disease
AU - Iwaki, Hirotaka
AU - Hughes, Katherine C.
AU - Gao, Xiang
AU - Schwarzschild, Michael A.
AU - Ascherio, Alberto
N1 - Funding Information:
We would like to thank the participants and staff of the Health Professional Follow-up Study for their valuable contributions as well as the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School.
Funding Information:
This study was supported by Department of Defense grant W81XWH-14-0131 . The HPFS cohort is funded by NIH grant UM1 CA167552 .
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/11/15
Y1 - 2018/11/15
N2 - Background: Previous studies regarding the association between restless legs syndrome (RLS) and Parkinson's disease (PD) have produced contradictory results. However, the time frame between them has varied across these studies, and also, the longitudinal trajectroy of RLS symptoms has not been considered. Objective: To investigate if transient or continuous/recurrent RLS identified by questionnaire are associated with the premotor symptoms of PD. Methods: The study population comprised 16,636 men in the Health Professional Follow-Up Study, who answered questions regarding RLS symptoms in both 2002 and 2008, and were not diagnosed with PD. Outcomes were self-reported constipation, possible REM sleep behavior disorder (pRBD) in 2012 and smell identification test score in 2014. Results: RLS was associated with increased odds of constipation, but only continuous/recurrent RLS status was associated with higher odds of having pRBD. RLS was not significantly associated with olfactory scores. Conclusion: In this large-scale longitudinal study, we found moderate associations between the presence of RLS and increased odds of having constipation and pRBD.
AB - Background: Previous studies regarding the association between restless legs syndrome (RLS) and Parkinson's disease (PD) have produced contradictory results. However, the time frame between them has varied across these studies, and also, the longitudinal trajectroy of RLS symptoms has not been considered. Objective: To investigate if transient or continuous/recurrent RLS identified by questionnaire are associated with the premotor symptoms of PD. Methods: The study population comprised 16,636 men in the Health Professional Follow-Up Study, who answered questions regarding RLS symptoms in both 2002 and 2008, and were not diagnosed with PD. Outcomes were self-reported constipation, possible REM sleep behavior disorder (pRBD) in 2012 and smell identification test score in 2014. Results: RLS was associated with increased odds of constipation, but only continuous/recurrent RLS status was associated with higher odds of having pRBD. RLS was not significantly associated with olfactory scores. Conclusion: In this large-scale longitudinal study, we found moderate associations between the presence of RLS and increased odds of having constipation and pRBD.
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U2 - 10.1016/j.jns.2018.08.028
DO - 10.1016/j.jns.2018.08.028
M3 - Article
C2 - 30212740
AN - SCOPUS:85053223861
SN - 0022-510X
VL - 394
SP - 41
EP - 44
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
ER -