TY - JOUR
T1 - The association of protein intake (amount and type) with ovarian antral follicle counts among infertile women
T2 - results from the EARTH prospective study cohort
AU - the EARTH Study Team
AU - Souter, I.
AU - Chiu, Y. H.
AU - Batsis, M.
AU - Afeiche, M. C.
AU - Williams, P. L.
AU - Hauser, R.
AU - Chavarro, J. E.
N1 - Funding Information:
Supported by grants: ES009718, ES000002 from the National Institute of Environmental Health Sciences (NIEHS), P30DK46200 and T32DK00770 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Ruth L. Kirschstein National Research Service Award T32 DK007703-16. The authors would like to thank Jennifer Ford, RN, and Myra Keller, RN, for their assistance with patient recruitment and specimen collection.
Funding Information:
Supported by grants: ES009718, ES000002 from the National Institute of Environmental Health Sciences (NIEHS), P30DK46200 and T32DK00770 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Ruth L. Kirschstein National Research Service Award T32 DK007703-16.
Publisher Copyright:
© 2017 Royal College of Obstetricians and Gynaecologists
PY - 2017/9
Y1 - 2017/9
N2 - Objective: To evaluate the association between protein intake (amount and type) and antral follicle count (AFC). Design: Prospective cohort. Setting: Academic fertility centre. Population: Two hundred and sixty-five women undergoing fertility treatments at an academic fertility centre and participating in an ongoing study on environment and reproductive health. Methods: We measured AFC in ultrasonographic evaluation among women undergoing infertility treatments. Women completed a previously validated semi-quantitative food frequency questionnaire. We used Poisson regression to evaluate the relation between protein intake and AFC while adjusting for age, body mass index, race, smoking status, and total energy intake. Main outcome measures: Antral follicle count. Results: Among 265 women (mean age: 35.0 ± 3.9 years, 85% Caucasian), total protein intake (% energy) was unrelated to AFC. When protein from different food sources was considered separately, we found a negative association between dairy protein intake and AFC. The mean AFC was 14.4% (3.9–23.7%) lower for women in the highest quintile of dairy protein intake than for women in the bottom quintile after adjusting for potential confounders (P-trend = 0.04). This association was stronger among women who had never smoked (P-trend = 0.002) but was not observed among previous smokers (P-trend = 0.36). There were no associations between protein intake from either non-dairy animal or vegetable sources and AFC. Conclusion: Higher dairy protein intake (≥5.24% of energy) was associated with lower antral follicle counts among women presenting for infertility treatment. These findings should be further investigated in prospective studies also designed to clarify the biology underlying the observed associations. Tweetable abstract: Higher dairy protein intake was associated with lower antral follicle counts in an infertile population.
AB - Objective: To evaluate the association between protein intake (amount and type) and antral follicle count (AFC). Design: Prospective cohort. Setting: Academic fertility centre. Population: Two hundred and sixty-five women undergoing fertility treatments at an academic fertility centre and participating in an ongoing study on environment and reproductive health. Methods: We measured AFC in ultrasonographic evaluation among women undergoing infertility treatments. Women completed a previously validated semi-quantitative food frequency questionnaire. We used Poisson regression to evaluate the relation between protein intake and AFC while adjusting for age, body mass index, race, smoking status, and total energy intake. Main outcome measures: Antral follicle count. Results: Among 265 women (mean age: 35.0 ± 3.9 years, 85% Caucasian), total protein intake (% energy) was unrelated to AFC. When protein from different food sources was considered separately, we found a negative association between dairy protein intake and AFC. The mean AFC was 14.4% (3.9–23.7%) lower for women in the highest quintile of dairy protein intake than for women in the bottom quintile after adjusting for potential confounders (P-trend = 0.04). This association was stronger among women who had never smoked (P-trend = 0.002) but was not observed among previous smokers (P-trend = 0.36). There were no associations between protein intake from either non-dairy animal or vegetable sources and AFC. Conclusion: Higher dairy protein intake (≥5.24% of energy) was associated with lower antral follicle counts among women presenting for infertility treatment. These findings should be further investigated in prospective studies also designed to clarify the biology underlying the observed associations. Tweetable abstract: Higher dairy protein intake was associated with lower antral follicle counts in an infertile population.
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U2 - 10.1111/1471-0528.14630
DO - 10.1111/1471-0528.14630
M3 - Article
C2 - 28278351
AN - SCOPUS:85017539485
SN - 1470-0328
VL - 124
SP - 1547
EP - 1555
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 10
ER -