The Association of Salivary Serotonin With Mood and Cardio-Autonomic Function: A Preliminary Report

Michał Seweryn Karbownik, Steven Daniel Hicks

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Serotonin plays an important role in mood regulation and depression. However, it is not clear whether the levels of serotonin in saliva are related to current mood. Aim: To test the association of salivary serotonin concentrations with mood, as well as cardiovascular and autonomic parameters. Materials and Methods: Saliva samples were obtained from collegiate runners and output parameters were examined before and after physical activity. Results: Salivary serotonin concentration was negatively associated with current mood (β = −0.32, 95%CI −0.62 to −0.02, p = 0.037, analysis adjusted for potential confounders), but insignificantly with measured cardiovascular and autonomic parameters. Conclusions: Salivary serotonin may reflect current mood. The results are preliminary and require further evaluation.

Original languageEnglish (US)
Article number788153
JournalFrontiers in Psychiatry
Volume13
DOIs
StatePublished - May 31 2022

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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