TY - JOUR
T1 - The Asthma Family Tree
T2 - Evaluating Associations Between Childhood, Parental, and Grandparental Asthma in Seven Chinese Cities
AU - Yu, Hongyao
AU - Su, Fan
AU - Wang, Le Bing
AU - Hemminki, Kari
AU - Dharmage, Shyamali C.
AU - Bowatte, Gayan
AU - Bui, Dinh
AU - Qian, Zhengmin
AU - Vaughn, Michael G.
AU - Aaron, Hannah E.
AU - Xiong, Shimin
AU - Shen, Xubo
AU - Zhou, Yuanzhong
AU - Zhou, Peien
AU - Zeng, Xiao Wen
AU - Chen, Gongbo
AU - Yang, Bo Yi
AU - Hu, Li Wen
AU - Dong, Guang Hui
N1 - Funding Information:
This study was supported by the National Key Research and Development Program of China (2018YFC1004300, 2018YFC1004302, and 2018YFE0106900), the National Natural Science Foundation of China (81872582 and 81872583), the Guangdong Provincial Natural Science Foundation Team Project (2018B030312005), the Science and Technology Program of Guangzhou (201807010032 and 201803010054), the Science and Technology Program of Zhongshan (2019B1110), and the Natural Science Foundation of Guangdong Province (2017A090905042, 2018B05052007, 2019A050510017, and 2020A1515011131). KH was sponsored by the European Union’s Horizon 2020 Research and Innovation Programme, Grant no. 856620.
Publisher Copyright:
© Copyright © 2021 Yu, Su, Wang, Hemminki, Dharmage, Bowatte, Bui, Qian, Vaughn, Aaron, Xiong, Shen, Zhou, Zhou, Zeng, Chen, Yang, Hu and Dong.
PY - 2021/10/27
Y1 - 2021/10/27
N2 - Objective: To evaluate the associations between childhood, parental, and grandparental asthma. Methods: We studied 59,484 children randomly selected from 94 kindergartens, elementary, and middle schools in seven Chinese cities from 2012 to 2013, using a cross-sectional survey-based study design. Information on their and their family members' (parents, paternal grandparents, and maternal grandparents) asthma status were reported by children's parents or guardians. Mixed effects logistic regressions were used to assess hereditary patterns of asthma and mediation analysis was performed to estimate the potential mediation effect of parents on the association between grandparental asthma and childhood asthma. Results: The magnitude of ORs for childhood asthma increased as the number of family members affected by asthma increased. Among children who had one family member with asthma, childhood asthma was associated with asthma in maternal grandmothers (OR: 2.08, 95% CI: 1.67–2.59), maternal grandfathers (OR: 2.08, 95% CI: 1.71–2.53), paternal grandmothers (OR: 2.40, 95% CI: 1.93–2.99), and paternal grandfathers (OR: 2.59, 95% CI: 2.14–3.13). Among children who had two family members with asthma, the highest asthma risk was found when both parents had asthma (OR: 15.92, 95% CI: 4.66–54.45). Parents had a small proportion of mediation effect (9–12%) on the association between grandparental asthma and childhood asthma. Conclusions: Grandparents with asthma were associated with childhood asthma and parents with asthma partially mediated the association.
AB - Objective: To evaluate the associations between childhood, parental, and grandparental asthma. Methods: We studied 59,484 children randomly selected from 94 kindergartens, elementary, and middle schools in seven Chinese cities from 2012 to 2013, using a cross-sectional survey-based study design. Information on their and their family members' (parents, paternal grandparents, and maternal grandparents) asthma status were reported by children's parents or guardians. Mixed effects logistic regressions were used to assess hereditary patterns of asthma and mediation analysis was performed to estimate the potential mediation effect of parents on the association between grandparental asthma and childhood asthma. Results: The magnitude of ORs for childhood asthma increased as the number of family members affected by asthma increased. Among children who had one family member with asthma, childhood asthma was associated with asthma in maternal grandmothers (OR: 2.08, 95% CI: 1.67–2.59), maternal grandfathers (OR: 2.08, 95% CI: 1.71–2.53), paternal grandmothers (OR: 2.40, 95% CI: 1.93–2.99), and paternal grandfathers (OR: 2.59, 95% CI: 2.14–3.13). Among children who had two family members with asthma, the highest asthma risk was found when both parents had asthma (OR: 15.92, 95% CI: 4.66–54.45). Parents had a small proportion of mediation effect (9–12%) on the association between grandparental asthma and childhood asthma. Conclusions: Grandparents with asthma were associated with childhood asthma and parents with asthma partially mediated the association.
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U2 - 10.3389/fped.2021.720273
DO - 10.3389/fped.2021.720273
M3 - Article
C2 - 34778126
AN - SCOPUS:85118926931
SN - 2296-2360
VL - 9
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 720273
ER -