TY - JOUR
T1 - The attributable risk of chronic obstructive pulmonary disease due to ambient fine particulate pollution among older adults
AU - Lin, Hualiang
AU - Qian, Zhengmin (Min)
AU - Guo, Yanfei
AU - Zheng, Yang
AU - Ai, Siqi
AU - Hang, Jian
AU - Wang, Xiaojie
AU - Zhang, Lingli
AU - Liu, Tao
AU - Guan, Weijie
AU - Li, Xing
AU - Xiao, Jianpeng
AU - Zeng, Weilin
AU - Xian, Hong
AU - Howard, Steven W.
AU - Ma, Wenjun
AU - Wu, Fan
N1 - Publisher Copyright:
© 2018
PY - 2018/4
Y1 - 2018/4
N2 - Background: The linkage between ambient fine particle pollution (PM2.5) and chronic obstructive pulmonary disease (COPD) and the attributable risk remained largely unknown. This study determined the cross-sectional association between ambient PM2.5 and prevalence of COPD among adults ≥50 years of age. Methods: We surveyed 29,290 participants aged 50 years and above in this study. The annual average concentrations of PM2.5 derived from satellite data were used as the exposure indicator. A mixed effect model was applied to determine the associations and the burden of COPD attributable to PM2.5. Results: Among the participants, 1872 (6.39%) were classified as COPD cases. Our analysis observed a threshold concentration of 30 μg/m3 in the PM2.5-COPD association, above which we found a linear positive exposure-response association between ambient PM2.5 and COPD. The odds ratio (OR) for each 10 μg/m3 increase in ambient PM2.5 was 1.21(95% CI: 1.13, 1.30). Stratified analyses suggested that males, older subjects (65 years and older) and those with lower education attainment might be the vulnerable subpopulations. We further estimated that about 13.79% (95% CI: 7.82%, 21.62%) of the COPD cases could be attributable to PM2.5 levels higher than 30 μg/m3 in the study population. Conclusion: Our analysis indicates that ambient PM2.5 exposure could increase the risk of COPD and accounts for a substantial fraction of COPD among the study population.
AB - Background: The linkage between ambient fine particle pollution (PM2.5) and chronic obstructive pulmonary disease (COPD) and the attributable risk remained largely unknown. This study determined the cross-sectional association between ambient PM2.5 and prevalence of COPD among adults ≥50 years of age. Methods: We surveyed 29,290 participants aged 50 years and above in this study. The annual average concentrations of PM2.5 derived from satellite data were used as the exposure indicator. A mixed effect model was applied to determine the associations and the burden of COPD attributable to PM2.5. Results: Among the participants, 1872 (6.39%) were classified as COPD cases. Our analysis observed a threshold concentration of 30 μg/m3 in the PM2.5-COPD association, above which we found a linear positive exposure-response association between ambient PM2.5 and COPD. The odds ratio (OR) for each 10 μg/m3 increase in ambient PM2.5 was 1.21(95% CI: 1.13, 1.30). Stratified analyses suggested that males, older subjects (65 years and older) and those with lower education attainment might be the vulnerable subpopulations. We further estimated that about 13.79% (95% CI: 7.82%, 21.62%) of the COPD cases could be attributable to PM2.5 levels higher than 30 μg/m3 in the study population. Conclusion: Our analysis indicates that ambient PM2.5 exposure could increase the risk of COPD and accounts for a substantial fraction of COPD among the study population.
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U2 - 10.1016/j.envint.2018.01.029
DO - 10.1016/j.envint.2018.01.029
M3 - Article
C2 - 29425898
AN - SCOPUS:85041397251
SN - 0160-4120
VL - 113
SP - 143
EP - 148
JO - Environment international
JF - Environment international
ER -