The basis for measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in serum

L. L. Needham, D. G. Patterson, J. L. Pirkle, L. O. Henderson, V. W. Burse

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Because procuring blood is a much less invasive procedure than procuring adipose tissue for conducting laboratory work in epidemiologic studies, we investigated in what fraction of blood 2,3,7,8-TCDD is located, the partitioning of 2,3,7,8-TCDD between serum and adipose tissue, and the effects of fasting on the levels of selected chlorinated hydrocarbons' in serum. In summary, we found that (1) 2,3,7,8-TCDD is associated almost completely with the lipoproteins in the plasma fraction, (2) its partitioning coefficient between serum and adipose tissue on a lipid basis is approximately one, and (3) when the levels are corrected for lipids, fasting has little effect on the levels of chlorinated hydrocarbons in serum.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
Issue number1-6
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • General Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis


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