TY - JOUR
T1 - The basis for measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in serum
AU - Needham, L. L.
AU - Patterson, D. G.
AU - Pirkle, J. L.
AU - Henderson, L. O.
AU - Burse, V. W.
N1 - Funding Information:
This study was funded in part by the Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333.
PY - 1989
Y1 - 1989
N2 - Because procuring blood is a much less invasive procedure than procuring adipose tissue for conducting laboratory work in epidemiologic studies, we investigated in what fraction of blood 2,3,7,8-TCDD is located, the partitioning of 2,3,7,8-TCDD between serum and adipose tissue, and the effects of fasting on the levels of selected chlorinated hydrocarbons' in serum. In summary, we found that (1) 2,3,7,8-TCDD is associated almost completely with the lipoproteins in the plasma fraction, (2) its partitioning coefficient between serum and adipose tissue on a lipid basis is approximately one, and (3) when the levels are corrected for lipids, fasting has little effect on the levels of chlorinated hydrocarbons in serum.
AB - Because procuring blood is a much less invasive procedure than procuring adipose tissue for conducting laboratory work in epidemiologic studies, we investigated in what fraction of blood 2,3,7,8-TCDD is located, the partitioning of 2,3,7,8-TCDD between serum and adipose tissue, and the effects of fasting on the levels of selected chlorinated hydrocarbons' in serum. In summary, we found that (1) 2,3,7,8-TCDD is associated almost completely with the lipoproteins in the plasma fraction, (2) its partitioning coefficient between serum and adipose tissue on a lipid basis is approximately one, and (3) when the levels are corrected for lipids, fasting has little effect on the levels of chlorinated hydrocarbons in serum.
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U2 - 10.1016/0045-6535(89)90151-3
DO - 10.1016/0045-6535(89)90151-3
M3 - Article
AN - SCOPUS:0024369770
SN - 0045-6535
VL - 18
SP - 425
EP - 430
JO - Chemosphere
JF - Chemosphere
IS - 1-6
ER -