The basis for measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in serum

L. L. Needham; D. G. Patterson; J. L. Pirkle; L. O. Henderson; V. W. Burse

doi:10.1016/0045-6535(89)90151-3

The basis for measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in serum

L. L. Needham
, D. G. Patterson
, J. L. Pirkle
, L. O. Henderson
, V. W. Burse

Forensic Science Program

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Because procuring blood is a much less invasive procedure than procuring adipose tissue for conducting laboratory work in epidemiologic studies, we investigated in what fraction of blood 2,3,7,8-TCDD is located, the partitioning of 2,3,7,8-TCDD between serum and adipose tissue, and the effects of fasting on the levels of selected chlorinated hydrocarbons' in serum. In summary, we found that (1) 2,3,7,8-TCDD is associated almost completely with the lipoproteins in the plasma fraction, (2) its partitioning coefficient between serum and adipose tissue on a lipid basis is approximately one, and (3) when the levels are corrected for lipids, fasting has little effect on the levels of chlorinated hydrocarbons in serum.

Original language	English (US)
Pages (from-to)	425-430
Number of pages	6
Journal	Chemosphere
Volume	18
Issue number	1-6
DOIs	https://doi.org/10.1016/0045-6535(89)90151-3
State	Published - 1989

All Science Journal Classification (ASJC) codes

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(89)90151-3

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title = "The basis for measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in serum",

abstract = "Because procuring blood is a much less invasive procedure than procuring adipose tissue for conducting laboratory work in epidemiologic studies, we investigated in what fraction of blood 2,3,7,8-TCDD is located, the partitioning of 2,3,7,8-TCDD between serum and adipose tissue, and the effects of fasting on the levels of selected chlorinated hydrocarbons' in serum. In summary, we found that (1) 2,3,7,8-TCDD is associated almost completely with the lipoproteins in the plasma fraction, (2) its partitioning coefficient between serum and adipose tissue on a lipid basis is approximately one, and (3) when the levels are corrected for lipids, fasting has little effect on the levels of chlorinated hydrocarbons in serum.",

author = "Needham, \{L. L.\} and Patterson, \{D. G.\} and Pirkle, \{J. L.\} and Henderson, \{L. O.\} and Burse, \{V. W.\}",

note = "Funding Information: This study was funded in part by the Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333.",

year = "1989",

doi = "10.1016/0045-6535(89)90151-3",

language = "English (US)",

volume = "18",

pages = "425--430",

journal = "Chemosphere",

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publisher = "Elsevier Limited",

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TY - JOUR

T1 - The basis for measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in serum

AU - Needham, L. L.

AU - Patterson, D. G.

AU - Pirkle, J. L.

AU - Henderson, L. O.

AU - Burse, V. W.

N1 - Funding Information: This study was funded in part by the Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333.

PY - 1989

Y1 - 1989

N2 - Because procuring blood is a much less invasive procedure than procuring adipose tissue for conducting laboratory work in epidemiologic studies, we investigated in what fraction of blood 2,3,7,8-TCDD is located, the partitioning of 2,3,7,8-TCDD between serum and adipose tissue, and the effects of fasting on the levels of selected chlorinated hydrocarbons' in serum. In summary, we found that (1) 2,3,7,8-TCDD is associated almost completely with the lipoproteins in the plasma fraction, (2) its partitioning coefficient between serum and adipose tissue on a lipid basis is approximately one, and (3) when the levels are corrected for lipids, fasting has little effect on the levels of chlorinated hydrocarbons in serum.

AB - Because procuring blood is a much less invasive procedure than procuring adipose tissue for conducting laboratory work in epidemiologic studies, we investigated in what fraction of blood 2,3,7,8-TCDD is located, the partitioning of 2,3,7,8-TCDD between serum and adipose tissue, and the effects of fasting on the levels of selected chlorinated hydrocarbons' in serum. In summary, we found that (1) 2,3,7,8-TCDD is associated almost completely with the lipoproteins in the plasma fraction, (2) its partitioning coefficient between serum and adipose tissue on a lipid basis is approximately one, and (3) when the levels are corrected for lipids, fasting has little effect on the levels of chlorinated hydrocarbons in serum.

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DO - 10.1016/0045-6535(89)90151-3

M3 - Article

AN - SCOPUS:0024369770

SN - 0045-6535

VL - 18

SP - 425

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JF - Chemosphere

IS - 1-6

ER -

The basis for measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in serum

Abstract

All Science Journal Classification (ASJC) codes

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