The cellular and molecular basis of store-operated calcium entry

Katrik Venkatachalam; Damian B. Van Rossum; Randen L. Patterson; Hong Tao Ma; Donald Gill

doi:10.1038/ncb1102-e263

The cellular and molecular basis of store-operated calcium entry

Katrik Venkatachalam, Damian B. Van Rossum, Randen L. Patterson, Hong Tao Ma, Donald Gill

Research output: Contribution to journal › Review article › peer-review

341 Scopus citations

Abstract

The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.

Original language	English (US)
Journal	Nature Cell Biology
Volume	4
Issue number	11
DOIs	https://doi.org/10.1038/ncb1102-e263
State	Published - Nov 1 2002

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1038/ncb1102-e263

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AU - Gill, Donald

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AB - The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.

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The cellular and molecular basis of store-operated calcium entry

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