The development and function of follicular helper T cells in immune responses

Maogen Chen; Zhiyong Guo; Weiqiang Ju; Bernhard Ryffel; Xiaoshun He; Song Guo Zheng

doi:10.1038/cmi.2012.18

The development and function of follicular helper T cells in immune responses

Maogen Chen, Zhiyong Guo, Weiqiang Ju, Bernhard Ryffel, Xiaoshun He, Song Guo Zheng

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.

Original language	English (US)
Pages (from-to)	375-379
Number of pages	5
Journal	Cellular and Molecular Immunology
Volume	9
Issue number	5
DOIs	https://doi.org/10.1038/cmi.2012.18
State	Published - Sep 2012

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Infectious Diseases

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10.1038/cmi.2012.18

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title = "The development and function of follicular helper T cells in immune responses",

abstract = "Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.",

author = "Maogen Chen and Zhiyong Guo and Weiqiang Ju and Bernhard Ryffel and Xiaoshun He and Zheng, {Song Guo}",

note = "Funding Information: This work was supported in part by grants from the National Institutes of Health R01 AR 059103, Arthritis Foundation; Wright Foundation; the Outstanding Youth Scientist Investigator Award from National Nature Science Foundation of China (30728007) and the American College of Rheumatology Research and Education{\textquoteright}s Within Our Reach: Finding a Cure for Rheumatoid Arthritis campaign (all to SGZ), National Nature Science Foundation of China (30972951) (XH) and Le Studium and European FEDER grant support (BR).",

year = "2012",

month = sep,

doi = "10.1038/cmi.2012.18",

language = "English (US)",

volume = "9",

pages = "375--379",

journal = "Cellular and Molecular Immunology",

issn = "1672-7681",

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T1 - The development and function of follicular helper T cells in immune responses

AU - Chen, Maogen

AU - Guo, Zhiyong

AU - Ju, Weiqiang

AU - Ryffel, Bernhard

AU - He, Xiaoshun

AU - Zheng, Song Guo

N1 - Funding Information: This work was supported in part by grants from the National Institutes of Health R01 AR 059103, Arthritis Foundation; Wright Foundation; the Outstanding Youth Scientist Investigator Award from National Nature Science Foundation of China (30728007) and the American College of Rheumatology Research and Education’s Within Our Reach: Finding a Cure for Rheumatoid Arthritis campaign (all to SGZ), National Nature Science Foundation of China (30972951) (XH) and Le Studium and European FEDER grant support (BR).

PY - 2012/9

Y1 - 2012/9

N2 - Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.

AB - Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.

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JO - Cellular and Molecular Immunology

JF - Cellular and Molecular Immunology

IS - 5

ER -

The development and function of follicular helper T cells in immune responses

Abstract

All Science Journal Classification (ASJC) codes

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