The development of catalytic nucleophilic substitution reactions: Challenges, progress and future directions

Jie An; Ross M. Denton; Tristan H. Lambert; Eric D. Nacsa

doi:10.1039/c4ob00032c

The development of catalytic nucleophilic substitution reactions: Challenges, progress and future directions

Jie An, Ross M. Denton, Tristan H. Lambert, Eric D. Nacsa

Chemistry

Research output: Contribution to journal › Review article › peer-review

109 Scopus citations

Abstract

Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis. This Article describes the emerging area of catalytic S_N2 reactions with specific emphasis on the design and development of phosphorus(v) and cyclopropenone-based catalytic S_N2 reactions of alcohols.

Original language	English (US)
Pages (from-to)	2993-3003
Number of pages	11
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	19
DOIs	https://doi.org/10.1039/c4ob00032c
State	Published - May 21 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c4ob00032c

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abstract = "Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis. This Article describes the emerging area of catalytic SN2 reactions with specific emphasis on the design and development of phosphorus(v) and cyclopropenone-based catalytic SN2 reactions of alcohols.",

author = "Jie An and Denton, {Ross M.} and Lambert, {Tristan H.} and Nacsa, {Eric D.}",

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AU - An, Jie

AU - Denton, Ross M.

AU - Lambert, Tristan H.

AU - Nacsa, Eric D.

PY - 2014/5/21

Y1 - 2014/5/21

N2 - Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis. This Article describes the emerging area of catalytic SN2 reactions with specific emphasis on the design and development of phosphorus(v) and cyclopropenone-based catalytic SN2 reactions of alcohols.

AB - Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis. This Article describes the emerging area of catalytic SN2 reactions with specific emphasis on the design and development of phosphorus(v) and cyclopropenone-based catalytic SN2 reactions of alcohols.

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AN - SCOPUS:84898826358

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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The development of catalytic nucleophilic substitution reactions: Challenges, progress and future directions

Abstract

All Science Journal Classification (ASJC) codes

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