TY - JOUR
T1 - The diverse contributions of fucose linkages in cancer
AU - Keeley, Tyler S.
AU - Yang, Shengyu
AU - Lau, Eric
N1 - Funding Information:
The authors would like to acknowledge funding from the Elsa U. Pardee Foundation and the National Cancer Institute (NCI) (R01 CA175741, R01 CA233844) to S.Y. and from the Harry J. Lloyd Charitable Trust Foundation (melanoma biology research grant) and NCI (5R00CA172705-05 and R01 CA241599-01) to E.L.
Publisher Copyright:
© 2019 by the authors.
PY - 2019/9
Y1 - 2019/9
N2 - Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.
AB - Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.
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U2 - 10.3390/cancers11091241
DO - 10.3390/cancers11091241
M3 - Article
C2 - 31450600
AN - SCOPUS:85071864069
SN - 2072-6694
VL - 11
JO - Cancers
JF - Cancers
IS - 9
M1 - 1241
ER -