TY - JOUR
T1 - The double-stranded-RNA-binding motif
T2 - Interference and much more
AU - Tian, Bin
AU - Bevilacqua, Philip C.
AU - Diegelman-Parente, Amy
AU - Mathews, Michael B.
N1 - Funding Information:
We thank B. Golden at Purdue University for assistance with figure 2 and H. Zhang at New Jersey Medical School for assistance with figure 4. Support from the following funding agencies is acknowledged: from the National Institutes of Health to P.C.B. and M.B.M. and from the American Cancer Society to A.D.P.
PY - 2004/12
Y1 - 2004/12
N2 - RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference and related phenomena. But double-stranded and highly structured RNAs have long been recognized as key players in cell processes ranging from RNA maturation and localization to the antiviral response in higher organisms. Penetrating insights into the metabolism and functions of such RNAs have come from the identification and study of proteins that contain the double-stranded-RNA-binding motif.
AB - RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference and related phenomena. But double-stranded and highly structured RNAs have long been recognized as key players in cell processes ranging from RNA maturation and localization to the antiviral response in higher organisms. Penetrating insights into the metabolism and functions of such RNAs have come from the identification and study of proteins that contain the double-stranded-RNA-binding motif.
UR - http://www.scopus.com/inward/record.url?scp=10044246238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10044246238&partnerID=8YFLogxK
U2 - 10.1038/nrm1528
DO - 10.1038/nrm1528
M3 - Review article
C2 - 15573138
AN - SCOPUS:10044246238
SN - 1471-0072
VL - 5
SP - 1013
EP - 1023
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 12
ER -