The double-stranded-RNA-binding motif: Interference and much more

Bin Tian; Philip C. Bevilacqua; Amy Diegelman-Parente; Michael B. Mathews

doi:10.1038/nrm1528

The double-stranded-RNA-binding motif: Interference and much more

Bin Tian
, Philip C. Bevilacqua
, Amy Diegelman-Parente
, Michael B. Mathews

Research output: Contribution to journal › Review article › peer-review

224 Scopus citations

Abstract

RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference and related phenomena. But double-stranded and highly structured RNAs have long been recognized as key players in cell processes ranging from RNA maturation and localization to the antiviral response in higher organisms. Penetrating insights into the metabolism and functions of such RNAs have come from the identification and study of proteins that contain the double-stranded-RNA-binding motif.

Original language	English (US)
Pages (from-to)	1013-1023
Number of pages	11
Journal	Nature Reviews Molecular Cell Biology
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nrm1528
State	Published - Dec 2004

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/nrm1528

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title = "The double-stranded-RNA-binding motif: Interference and much more",

abstract = "RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference and related phenomena. But double-stranded and highly structured RNAs have long been recognized as key players in cell processes ranging from RNA maturation and localization to the antiviral response in higher organisms. Penetrating insights into the metabolism and functions of such RNAs have come from the identification and study of proteins that contain the double-stranded-RNA-binding motif.",

author = "Bin Tian and Bevilacqua, \{Philip C.\} and Amy Diegelman-Parente and Mathews, \{Michael B.\}",

note = "Funding Information: We thank B. Golden at Purdue University for assistance with figure 2 and H. Zhang at New Jersey Medical School for assistance with figure 4. Support from the following funding agencies is acknowledged: from the National Institutes of Health to P.C.B. and M.B.M. and from the American Cancer Society to A.D.P.",

year = "2004",

month = dec,

doi = "10.1038/nrm1528",

language = "English (US)",

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journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

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T1 - The double-stranded-RNA-binding motif

T2 - Interference and much more

AU - Tian, Bin

AU - Bevilacqua, Philip C.

AU - Diegelman-Parente, Amy

AU - Mathews, Michael B.

N1 - Funding Information: We thank B. Golden at Purdue University for assistance with figure 2 and H. Zhang at New Jersey Medical School for assistance with figure 4. Support from the following funding agencies is acknowledged: from the National Institutes of Health to P.C.B. and M.B.M. and from the American Cancer Society to A.D.P.

PY - 2004/12

Y1 - 2004/12

N2 - RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference and related phenomena. But double-stranded and highly structured RNAs have long been recognized as key players in cell processes ranging from RNA maturation and localization to the antiviral response in higher organisms. Penetrating insights into the metabolism and functions of such RNAs have come from the identification and study of proteins that contain the double-stranded-RNA-binding motif.

AB - RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference and related phenomena. But double-stranded and highly structured RNAs have long been recognized as key players in cell processes ranging from RNA maturation and localization to the antiviral response in higher organisms. Penetrating insights into the metabolism and functions of such RNAs have come from the identification and study of proteins that contain the double-stranded-RNA-binding motif.

UR - https://www.scopus.com/pages/publications/10044246238

UR - https://www.scopus.com/pages/publications/10044246238#tab=citedBy

U2 - 10.1038/nrm1528

DO - 10.1038/nrm1528

M3 - Review article

C2 - 15573138

AN - SCOPUS:10044246238

SN - 1471-0072

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SP - 1013

EP - 1023

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 12

ER -

The double-stranded-RNA-binding motif: Interference and much more

Abstract

All Science Journal Classification (ASJC) codes

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