The DXS423E gene in XP11.21 escapes X chromosome inactivation

Carolyn J. Brown; Andrew P. Miller; Laura Carrel; Jim L. Rupert; Kay E. Davies; Huntington F. Willard

doi:10.1093/hmg/4.2.251

The DXS423E gene in XP11.21 escapes X chromosome inactivation

Carolyn J. Brown, Andrew P. Miller, Laura Carrel, Jim L. Rupert, Kay E. Davies, Huntington F. Willard

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

Original language	English (US)
Pages (from-to)	251-255
Number of pages	5
Journal	Human molecular genetics
Volume	4
Issue number	2
DOIs	https://doi.org/10.1093/hmg/4.2.251
State	Published - Feb 1995

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Genetics(clinical)

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title = "The DXS423E gene in XP11.21 escapes X chromosome inactivation",

abstract = "The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.",

author = "Brown, {Carolyn J.} and Miller, {Andrew P.} and Laura Carrel and Rupert, {Jim L.} and Davies, {Kay E.} and Willard, {Huntington F.}",

note = "Funding Information: We would like to thank Michelle Ghert, Angelo Vivona and Ron Lafreniere for technical assistance and Colin Cooper for sharing data and information. This work was supported by NIH grant GM45441.",

year = "1995",

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doi = "10.1093/hmg/4.2.251",

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T1 - The DXS423E gene in XP11.21 escapes X chromosome inactivation

AU - Brown, Carolyn J.

AU - Miller, Andrew P.

AU - Carrel, Laura

AU - Rupert, Jim L.

AU - Davies, Kay E.

AU - Willard, Huntington F.

N1 - Funding Information: We would like to thank Michelle Ghert, Angelo Vivona and Ron Lafreniere for technical assistance and Colin Cooper for sharing data and information. This work was supported by NIH grant GM45441.

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N2 - The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

AB - The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

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The DXS423E gene in XP11.21 escapes X chromosome inactivation

Abstract

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