The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection

Robert L. Kirkman; Leslie V. Barrett; Glen N. Gaulton; Vicki E. Kelley; Walter Koltun; Frederick J. Schoen; Armelle Ythier; Terry B. Strom

doi:10.1097/00007890-198512000-00029

The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection

Robert L. Kirkman, Leslie V. Barrett, Glen N. Gaulton, Vicki E. Kelley, Walter Koltun, Frederick J. Schoen, Armelle Ythier, Terry B. Strom

Research output: Contribution to journal › Article › peer-review

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Abstract

During immune response to an allograft, activated T cells express a number of cell surface activation antigens, among them the membrane receptor for the lymphokine interleukin 2 (IL-2). As the IL-2 receptor is not present on resting T cells, it offers an attractive target for potentially specific immunosuppressive therapy. The rat monoclonal antibody M7/20, which binds to the murine IL-2 receptor, was studied for its effect on allograft survival in two H-2-incompatible strain combinations in inbred mice. Treatment with M7/20 for 10 days markedly prolonged survival of vascularized, hetero topic heart allografts in both strain combinations, with indefinite graft survival in 50% of recipients. The same treatment significantly prolonged skin allograft survival in one of the two combinations. The results support the important role of the IL-2 receptor in the mechanism of graft rejection and confirm its suitability as a target for immunosuppressive therapy in transplantation.

Original language	English (US)
Pages (from-to)	719-722
Number of pages	4
Journal	Transplantation
Volume	40
Issue number	6
DOIs	https://doi.org/10.1097/00007890-198512000-00029
State	Published - Dec 1985

All Science Journal Classification (ASJC) codes

Transplantation

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10.1097/00007890-198512000-00029

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title = "The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection",

abstract = "During immune response to an allograft, activated T cells express a number of cell surface activation antigens, among them the membrane receptor for the lymphokine interleukin 2 (IL-2). As the IL-2 receptor is not present on resting T cells, it offers an attractive target for potentially specific immunosuppressive therapy. The rat monoclonal antibody M7/20, which binds to the murine IL-2 receptor, was studied for its effect on allograft survival in two H-2-incompatible strain combinations in inbred mice. Treatment with M7/20 for 10 days markedly prolonged survival of vascularized, hetero topic heart allografts in both strain combinations, with indefinite graft survival in 50% of recipients. The same treatment significantly prolonged skin allograft survival in one of the two combinations. The results support the important role of the IL-2 receptor in the mechanism of graft rejection and confirm its suitability as a target for immunosuppressive therapy in transplantation.",

author = "Kirkman, {Robert L.} and Barrett, {Leslie V.} and Gaulton, {Glen N.} and Kelley, {Vicki E.} and Walter Koltun and Schoen, {Frederick J.} and Armelle Ythier and Strom, {Terry B.}",

year = "1985",

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language = "English (US)",

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journal = "Transplantation",

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AU - Kirkman, Robert L.

AU - Barrett, Leslie V.

AU - Gaulton, Glen N.

AU - Kelley, Vicki E.

AU - Koltun, Walter

AU - Schoen, Frederick J.

AU - Ythier, Armelle

AU - Strom, Terry B.

PY - 1985/12

Y1 - 1985/12

N2 - During immune response to an allograft, activated T cells express a number of cell surface activation antigens, among them the membrane receptor for the lymphokine interleukin 2 (IL-2). As the IL-2 receptor is not present on resting T cells, it offers an attractive target for potentially specific immunosuppressive therapy. The rat monoclonal antibody M7/20, which binds to the murine IL-2 receptor, was studied for its effect on allograft survival in two H-2-incompatible strain combinations in inbred mice. Treatment with M7/20 for 10 days markedly prolonged survival of vascularized, hetero topic heart allografts in both strain combinations, with indefinite graft survival in 50% of recipients. The same treatment significantly prolonged skin allograft survival in one of the two combinations. The results support the important role of the IL-2 receptor in the mechanism of graft rejection and confirm its suitability as a target for immunosuppressive therapy in transplantation.

AB - During immune response to an allograft, activated T cells express a number of cell surface activation antigens, among them the membrane receptor for the lymphokine interleukin 2 (IL-2). As the IL-2 receptor is not present on resting T cells, it offers an attractive target for potentially specific immunosuppressive therapy. The rat monoclonal antibody M7/20, which binds to the murine IL-2 receptor, was studied for its effect on allograft survival in two H-2-incompatible strain combinations in inbred mice. Treatment with M7/20 for 10 days markedly prolonged survival of vascularized, hetero topic heart allografts in both strain combinations, with indefinite graft survival in 50% of recipients. The same treatment significantly prolonged skin allograft survival in one of the two combinations. The results support the important role of the IL-2 receptor in the mechanism of graft rejection and confirm its suitability as a target for immunosuppressive therapy in transplantation.

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The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection

Abstract

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