The effect of apolipoprotein E genotype on neuron specific enolase and S-100β levels after cardiac surgery

W. Andrew Kofke, Patrick Konitzer, Qing Cheng Meng, Jia Guo, Albert Cheung

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We tested the hypothesis that two biochemical markers of brain injury would be increased after cardiac surgery in patients with the apolipoprotein (Apo) ε4 allele. Arterial blood samples were drawn before and 8 and 24 h after induction of anesthesia and later assayed for neuron specific enolase (NSE), S-100β, and apoE genotype. There was a highly significant temporal effect with increases in NSE (2.2 ± 1.6 ng/L to 11.8 ± 8.9 ng/L; P < 0.0001) (mean ± SD) and S-100β (0.15 ± 0.1 μg/L to 0.45 ± 0.42 μg/L, P < 0.0001). At 8 and 24 h after induction of anesthesia S-100β (0.28 ± 0.18 μg/L versus 0.91 ± 0.54 μg/L; P = 0.004) and NSE (8.6 ± 5.6 ng/L versus 19.0 ± 19.7 ng/L; P = 0.02) levels, respectively, were higher in patients with the Apoε4 allele. Patients with the Apoε4 allele may be more susceptible to perioperative neural insults.

Original languageEnglish (US)
Pages (from-to)1323-1325
Number of pages3
JournalAnesthesia and analgesia
Volume99
Issue number5
DOIs
StatePublished - Nov 2004

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Fingerprint

Dive into the research topics of 'The effect of apolipoprotein E genotype on neuron specific enolase and S-100β levels after cardiac surgery'. Together they form a unique fingerprint.

Cite this