TY - JOUR
T1 - The effect of dexamethasone-21-acetate on meal size, meal frequency and macronutrient self-selection in rats
AU - Grigson, Patricia Sue
AU - Johnson, Deanne F.
AU - Collier, George H.
AU - Flaherty, Charles F.
PY - 1989/8
Y1 - 1989/8
N2 - In Experiment 1, the measurement of 24-hour food intake in two rats showed that treatment with dexamethasone-21-acetate (DEX) (0.5 mg/kg IP) produced a decrease in body weight which was at least partially due to a decrease in food intake (both meal frequency and meal size). In Experiment 2, the daily intake of three macronutrient sources was measured. These data showed that treatment with DEX (0.5 and 1.0 mg/kg IP) led to an acute increase in protein intake, a sustained decrease in fat intake and no change in carbohydrate consumption. We suggest that this change in macronutrient selection may be an adaptive response which serves to ameliorate some of the effects of DEX treatment.
AB - In Experiment 1, the measurement of 24-hour food intake in two rats showed that treatment with dexamethasone-21-acetate (DEX) (0.5 mg/kg IP) produced a decrease in body weight which was at least partially due to a decrease in food intake (both meal frequency and meal size). In Experiment 2, the daily intake of three macronutrient sources was measured. These data showed that treatment with DEX (0.5 and 1.0 mg/kg IP) led to an acute increase in protein intake, a sustained decrease in fat intake and no change in carbohydrate consumption. We suggest that this change in macronutrient selection may be an adaptive response which serves to ameliorate some of the effects of DEX treatment.
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U2 - 10.1016/0031-9384(89)90258-8
DO - 10.1016/0031-9384(89)90258-8
M3 - Article
C2 - 2602461
AN - SCOPUS:0024468410
SN - 0031-9384
VL - 46
SP - 211
EP - 216
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 2
ER -