The Effect of Hypoxia and 2,4 Dinitrophenol on Human Placental Glycogen Metabolism

Laurence M. Demers, Steven G. Gabbe, Claude A. Villee, Roy O. Greep

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The effects of 2,4 dinitrophenol and severe hypoxia (1% oxygen) on human placental glycogen metabolism were studied in immature and term human placental villi isolated in an organ culture system. It was observed that both treatments evoked similar changes in human placental glycogen turnover in terms of an acute dependent to independent form synthetase enzyme shift, an activation of the glycogen phosphorylase enzyme system, and a rapid breakdown in placental glycogen. These enzyme changes are consistent with an alteration in intracellular ATP, a known effect of these treatments, and suggest that human placental glycogen may be important to the metabolic energy balance of placental tissue during the course of gestation.

Original languageEnglish (US)
Pages (from-to)724-728
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Jun 1972

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'The Effect of Hypoxia and 2,4 Dinitrophenol on Human Placental Glycogen Metabolism'. Together they form a unique fingerprint.

Cite this