The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty

E. J. Susman; J. W. Finkelstein; V. M. Chinchilli; J. Schwab; L. S. Liben; M. R. D'Arcangelo; J. Meinke; L. M. Demers; G. Lookingbill; H. E. Kulin

doi:10.1016/S0022-3476(98)70061-7

The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty

E. J. Susman, J. W. Finkelstein, V. M. Chinchilli, J. Schwab, L. S. Liben, M. R. D'Arcangelo, J. Meinke, L. M. Demers, G. Lookingbill, H. E. Kulin

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Objective: The objective of this clinical study was to determine the effects of sex steroids on behavior and mood in adolescents with hypogonadism. Study design: The experimental design consisted of a randomized, double-blind, placebo-controlled, crossover trial lasting for 21 months. The study group consisted of 39 boys and 16 girls recruited from a pediatric endocrine clinic for delayed puberty. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks, alternating with placebo, at 3 dose levels approximating early, middle, and late pubertal amounts. The Child Behavior Checklist, Youth Self Report, Differential Emotion Scale, and Daily Mood Diary were administered after each placebo and treatment period to ascertain the effect of sex steroids on self- and parent-reported behavior problems and moods. Results: The data demonstrated only one significant treatment effect, namely, an increase in withdrawn behavior problems during administration of low-dose estrogen in girls. There were no consistent sex differences. Conclusion: These results demonstrate that administered testosterone or estrogen has minimal effects on behavior problems or mood in adolescents.

Original language	English (US)
Pages (from-to)	521-525
Number of pages	5
Journal	Journal of Pediatrics
Volume	133
Issue number	4
DOIs	https://doi.org/10.1016/S0022-3476(98)70061-7
State	Published - 1998

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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title = "The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty",

abstract = "Objective: The objective of this clinical study was to determine the effects of sex steroids on behavior and mood in adolescents with hypogonadism. Study design: The experimental design consisted of a randomized, double-blind, placebo-controlled, crossover trial lasting for 21 months. The study group consisted of 39 boys and 16 girls recruited from a pediatric endocrine clinic for delayed puberty. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks, alternating with placebo, at 3 dose levels approximating early, middle, and late pubertal amounts. The Child Behavior Checklist, Youth Self Report, Differential Emotion Scale, and Daily Mood Diary were administered after each placebo and treatment period to ascertain the effect of sex steroids on self- and parent-reported behavior problems and moods. Results: The data demonstrated only one significant treatment effect, namely, an increase in withdrawn behavior problems during administration of low-dose estrogen in girls. There were no consistent sex differences. Conclusion: These results demonstrate that administered testosterone or estrogen has minimal effects on behavior problems or mood in adolescents.",

author = "Susman, {E. J.} and Finkelstein, {J. W.} and Chinchilli, {V. M.} and J. Schwab and Liben, {L. S.} and D'Arcangelo, {M. R.} and J. Meinke and Demers, {L. M.} and G. Lookingbill and Kulin, {H. E.}",

note = "Funding Information: Supported by National Institutes of Health grants RO1-26636 and MO1-RR10732 and by a grant from the Genentech Foundation for Growth and Development. ",

year = "1998",

doi = "10.1016/S0022-3476(98)70061-7",

language = "English (US)",

volume = "133",

pages = "521--525",

journal = "Journal of Pediatrics",

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T1 - The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty

AU - Susman, E. J.

AU - Finkelstein, J. W.

AU - Chinchilli, V. M.

AU - Schwab, J.

AU - Liben, L. S.

AU - D'Arcangelo, M. R.

AU - Meinke, J.

AU - Demers, L. M.

AU - Lookingbill, G.

AU - Kulin, H. E.

N1 - Funding Information: Supported by National Institutes of Health grants RO1-26636 and MO1-RR10732 and by a grant from the Genentech Foundation for Growth and Development.

PY - 1998

Y1 - 1998

N2 - Objective: The objective of this clinical study was to determine the effects of sex steroids on behavior and mood in adolescents with hypogonadism. Study design: The experimental design consisted of a randomized, double-blind, placebo-controlled, crossover trial lasting for 21 months. The study group consisted of 39 boys and 16 girls recruited from a pediatric endocrine clinic for delayed puberty. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks, alternating with placebo, at 3 dose levels approximating early, middle, and late pubertal amounts. The Child Behavior Checklist, Youth Self Report, Differential Emotion Scale, and Daily Mood Diary were administered after each placebo and treatment period to ascertain the effect of sex steroids on self- and parent-reported behavior problems and moods. Results: The data demonstrated only one significant treatment effect, namely, an increase in withdrawn behavior problems during administration of low-dose estrogen in girls. There were no consistent sex differences. Conclusion: These results demonstrate that administered testosterone or estrogen has minimal effects on behavior problems or mood in adolescents.

AB - Objective: The objective of this clinical study was to determine the effects of sex steroids on behavior and mood in adolescents with hypogonadism. Study design: The experimental design consisted of a randomized, double-blind, placebo-controlled, crossover trial lasting for 21 months. The study group consisted of 39 boys and 16 girls recruited from a pediatric endocrine clinic for delayed puberty. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks, alternating with placebo, at 3 dose levels approximating early, middle, and late pubertal amounts. The Child Behavior Checklist, Youth Self Report, Differential Emotion Scale, and Daily Mood Diary were administered after each placebo and treatment period to ascertain the effect of sex steroids on self- and parent-reported behavior problems and moods. Results: The data demonstrated only one significant treatment effect, namely, an increase in withdrawn behavior problems during administration of low-dose estrogen in girls. There were no consistent sex differences. Conclusion: These results demonstrate that administered testosterone or estrogen has minimal effects on behavior problems or mood in adolescents.

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The effect of sex hormone replacement therapy on behavior problems and moods in adolescents with delayed puberty

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