TY - JOUR
T1 - The effects of apamin in rats with pretrigeminal or high spinal transsection of the central nervous system
AU - Janicki, P.
AU - Gumulka, S. W.
AU - Krzaścik, P.
AU - Habermann, E.
N1 - Funding Information:
Acknowledgment - This study was supported by the Alexander von Humboldt Foundation
PY - 1985
Y1 - 1985
N2 - P. Janicki, S.W. Gumulka, P. Krzaścik and E. Habermann. The effects of apamin in rats with pretrigeminal or high spinal transsection of the central nervous system. Toxicon 23, 993-996, 1985. - Rats were injected in one lateral cerebral ventricle (i.c.v.) with apamin (100 ng per animal). The resulting desynchronisation pattern in the electrocorticogram (ECoG) and the symptoms of poisoning were monitored before and after transsection at different levels, and following morphine. Apamin acts primarily on the brain stem and spinal cord, i.e. structures possessing a sensory input, and then indirectly on the higher integrating systems. There is no general parallelism between receptor density and locus of action.
AB - P. Janicki, S.W. Gumulka, P. Krzaścik and E. Habermann. The effects of apamin in rats with pretrigeminal or high spinal transsection of the central nervous system. Toxicon 23, 993-996, 1985. - Rats were injected in one lateral cerebral ventricle (i.c.v.) with apamin (100 ng per animal). The resulting desynchronisation pattern in the electrocorticogram (ECoG) and the symptoms of poisoning were monitored before and after transsection at different levels, and following morphine. Apamin acts primarily on the brain stem and spinal cord, i.e. structures possessing a sensory input, and then indirectly on the higher integrating systems. There is no general parallelism between receptor density and locus of action.
UR - https://www.scopus.com/pages/publications/0022388298
UR - https://www.scopus.com/pages/publications/0022388298#tab=citedBy
U2 - 10.1016/0041-0101(85)90392-7
DO - 10.1016/0041-0101(85)90392-7
M3 - Article
C2 - 4095709
AN - SCOPUS:0022388298
SN - 0041-0101
VL - 23
SP - 993
EP - 996
JO - Toxicon
JF - Toxicon
IS - 6
ER -