The Effects of Cardiopulmonary Bypass on Drug Pharmacology

Jens Fassl; Berend Mets

doi:10.1017/9781108297783.025

The Effects of Cardiopulmonary Bypass on Drug Pharmacology

Jens Fassl, Berend Mets

Department of Anesthesiology and Perioperative Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The institution of CPB has profound effects on the plasma concentration, distribution and elimination of drugs. The major factors responsible for this are haemodilution, altered plasma protein binding, altered regional blood flow, hypothermia, isolation of the lungs from the circulation and sequestration of drugs into components of the extracorporeal circuit. These changes, which are influenced by physicochemical and pharmacokinetic characteristics, result in an alteration in free drug and effector-site concentration.

Original language	English (US)
Title of host publication	Core Topics in Cardiac Anaesthesia
Publisher	Cambridge University Press
Pages	199-202
Number of pages	4
ISBN (Electronic)	9781108297783
ISBN (Print)	9781108419383
DOIs	https://doi.org/10.1017/9781108297783.025
State	Published - Jan 1 2020

All Science Journal Classification (ASJC) codes

General Medicine

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10.1017/9781108297783.025

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The Effects of Cardiopulmonary Bypass on Drug Pharmacology

Abstract

All Science Journal Classification (ASJC) codes

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