The Effects of Cardiopulmonary Bypass on Drug Pharmacology

Jens Fassl, Berend Mets

Research output: Chapter in Book/Report/Conference proceedingChapter


The institution of CPB has profound effects on the plasma concentration, distribution and elimination of drugs. The major factors responsible for this are haemodilution, altered plasma protein binding, altered regional blood flow, hypothermia, isolation of the lungs from the circulation and sequestration of drugs into components of the extracorporeal circuit. These changes, which are influenced by physicochemical and pharmacokinetic characteristics, result in an alteration in free drug and effector-site concentration.

Original languageEnglish (US)
Title of host publicationCore Topics in Cardiac Anaesthesia
PublisherCambridge University Press
Number of pages4
ISBN (Electronic)9781108297783
ISBN (Print)9781108419383
StatePublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • General Medicine

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