TY - JOUR
T1 - The effects of child abuse and neglect on cognitive functioning in adulthood
AU - Gould, Felicia
AU - Clarke, Jennifer
AU - Heim, Christine
AU - Harvey, Philip D.
AU - Majer, Matthias
AU - Nemeroff, Charles B.
N1 - Funding Information:
Support for this research was provided by a National Institute of Mental Health grant, MH-58922 , which was awarded to Dr. Nemeroff.
Funding Information:
Financial Disclosures unaffected by the publication of this work: Author Disclosure Information: Dr. Gould receives salary support from a clinical trial funded by Sepracor. Dr. Clarke reports no financial relationships with commercial interests. Dr. Heim reports no financial relationships with commercial interests. Dr. Harvey: Dr. Harvey has received consulting fees from Abbott Labs, Bristol Myers Squibb, Cypress Bioscience, En Vivo, Genentech, Johnson and Johnson, Merck and Company, Shire Pharma, and Sunovion Pharma during the past year. Dr. Majer reports no financial relationships with commercial interests Dr. Nemeroff discloses the following: Consulting: Xhale, Takeda; Stockholder: CeNeRx BioPharma, NovaDel Pharma, Inc., PharmaNeuroBoost, Revaax Pharma, Xhale; Other financial interests: CeNeRx BioPharma, PharmaNeuroBoost; Patents: Method and devices for transdermal delivery of lithium (US 6,375,990B1), Method of assessing antidepressant drug therapy via transport inhibition of monoamine neurotransmitters by ex vivo assay (US 7,148,027B2); Scientific Advisory Boards: American Foundation for Suicide Prevention (AFSP), CeNeRx BioPharma, National Alliance for Research on Schizophrenia and Depression (NARSAD), NovaDel Pharma, Inc., PharmaNeuroBoost, Anxiety Disorders Association of America (ADAA); Board of Directors: AFSP, NovaDel Pharma, Inc.; Research Grants: National Institutes of Health (NIH), Agency for Healthcare Research and Quality (AHRQ).
PY - 2012/4
Y1 - 2012/4
N2 - Aims: Recent research has revealed that early life trauma (ELS), including abuse (sexual and/or physical) and neglect, produce lasting changes in the CNS. We posited that cognitive deficits, often observed in psychiatric patients, result, in part, due to the neurobiological consequences of ELS. Additionally, we hypothesized that the nature and magnitude of cognitive deficits would differ according to the subtype of ELS experienced. Method: The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess neurocognitive functioning in 93 subjects (60 with ELS and 33 without). In the patients with a history of ELS, 35% and 16.7%, respectively, met criteria for current major depression and PTSD. Results: Significant associations between ELS status and CANTAB measures of memory and executive and emotional functioning were found. Conclusions: These data suggest that exposure to ELS results in a cascade of neurobiological changes associated with cognitive deficits in adulthood that vary according to the type of trauma experienced.
AB - Aims: Recent research has revealed that early life trauma (ELS), including abuse (sexual and/or physical) and neglect, produce lasting changes in the CNS. We posited that cognitive deficits, often observed in psychiatric patients, result, in part, due to the neurobiological consequences of ELS. Additionally, we hypothesized that the nature and magnitude of cognitive deficits would differ according to the subtype of ELS experienced. Method: The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess neurocognitive functioning in 93 subjects (60 with ELS and 33 without). In the patients with a history of ELS, 35% and 16.7%, respectively, met criteria for current major depression and PTSD. Results: Significant associations between ELS status and CANTAB measures of memory and executive and emotional functioning were found. Conclusions: These data suggest that exposure to ELS results in a cascade of neurobiological changes associated with cognitive deficits in adulthood that vary according to the type of trauma experienced.
UR - https://www.scopus.com/pages/publications/84858280398
UR - https://www.scopus.com/pages/publications/84858280398#tab=citedBy
U2 - 10.1016/j.jpsychires.2012.01.005
DO - 10.1016/j.jpsychires.2012.01.005
M3 - Article
C2 - 22336639
AN - SCOPUS:84858280398
SN - 0022-3956
VL - 46
SP - 500
EP - 506
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 4
ER -
SDG 3 Good Health and Well-being
SDG 16 Peace, Justice and Strong Institutions