The effects of chronic treatment with N-tert-butyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats

Thomas J. Gould; Paula C. Bickford

doi:10.1016/0006-8993(94)91308-0

The effects of chronic treatment with N-tert-butyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats

Thomas J. Gould, Paula C. Bickford

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-α-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21-22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.

Original language	English (US)
Pages (from-to)	333-336
Number of pages	4
Journal	Brain research
Volume	660
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)91308-0
State	Published - Oct 17 1994

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "The effects of chronic treatment with N-tert-butyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats",

abstract = "We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-α-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21-22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.",

author = "Gould, \{Thomas J.\} and Bickford, \{Paula C.\}",

note = "Funding Information: This work was supported by USPHS and the VAMRS.",

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AU - Bickford, Paula C.

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PY - 1994/10/17

Y1 - 1994/10/17

N2 - We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-α-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21-22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.

AB - We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-α-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21-22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.

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The effects of chronic treatment with N-tert-butyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats

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