The effects of Cl-PFESAs exposure on blood lipids – A community-based large population study in Guangzhou

Xin Mi, Lu Yin Wu, Jiao Jiao Liu, Qiu Ling Fang, Zhengmin (Min) Qian, Chu Chu, Qing Qing Li, Fan Su, Yun Ting Zhang, Peien Zhou, Xiao Wen Zeng, Hong Yao Yu, Pengxin Dong, Yang Zhou, Yanqiu Ou, Shimin Xiong, Xubo Shen, Wenru Feng, Yuanzhong Zhou, Guang Hui Dong

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Numerous epidemiological studies have investigated the lipid interference effects of legacy PFASs, however, no studies on PFAS alternatives and blood lipids have been published. In this study, we explored the association between Cl-PFESAs, a typical PFASs alternative in China, and blood lipid profiles in 1336 Guangzhou community residents using linear and non-linear regression models. The results showed a deleterious effect of Cl-PFESAs and blood lipids: adjusted estimates (β) for TC, TG, LDL-C and HDL-C per natural log unit increase of 6:2 Cl-PFESA were 0.029 (95% CI: 0.020, 0.038), 0.075 (95% CI: 0.049, 0.101), 0.035 (95% CI: 0.021, 0.049) and −0.071 (95% CI: −0.084, −0.058), respectively. The association between Cl-PFESAs and dyslipidemia was also positively significant (P < 0.05). Furthermore, a non-linear relationship was observed in Cl-PFESAs and serum lipid levels using a restricted cubic splines (RCS) model. In summary, our research suggested a negative impact of Cl-PFESAs on blood lipid patterns and a possible non-linear association.

Original languageEnglish (US)
Article number150634
JournalScience of the Total Environment
StatePublished - Feb 1 2022

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution


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