The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity

Juraj Sprung; William Castellani; Venkatramana Srinivasan; Solur Udayashankar

doi:10.1097/00000539-199811000-00043

The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity

Juraj Sprung
, William Castellani
, Venkatramana Srinivasan
, Solur Udayashankar

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

IMPLICATIONS: We present a case of neuromuscular block of unusual duration in a patient with atypical pseudocholinesterase activity who was taking the acetylcholinesterase inhibitor donepezil and who received succinylcholine and neostigmine as a part of her general anesthesia. To determine the possible role of donepezil in the prolonged neuromuscular block encountered in our patient, we studied the in vitro effects of donepezil on pseudocholinesterase.

Original language	English (US)
Pages (from-to)	1203-1205
Number of pages	3
Journal	Anesthesia and analgesia
Volume	87
Issue number	5
DOIs	https://doi.org/10.1097/00000539-199811000-00043
State	Published - Nov 14 1998

All Science Journal Classification (ASJC) codes

Anesthesiology and Pain Medicine

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10.1097/00000539-199811000-00043

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abstract = "IMPLICATIONS: We present a case of neuromuscular block of unusual duration in a patient with atypical pseudocholinesterase activity who was taking the acetylcholinesterase inhibitor donepezil and who received succinylcholine and neostigmine as a part of her general anesthesia. To determine the possible role of donepezil in the prolonged neuromuscular block encountered in our patient, we studied the in vitro effects of donepezil on pseudocholinesterase.",

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AU - Srinivasan, Venkatramana

AU - Udayashankar, Solur

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AB - IMPLICATIONS: We present a case of neuromuscular block of unusual duration in a patient with atypical pseudocholinesterase activity who was taking the acetylcholinesterase inhibitor donepezil and who received succinylcholine and neostigmine as a part of her general anesthesia. To determine the possible role of donepezil in the prolonged neuromuscular block encountered in our patient, we studied the in vitro effects of donepezil on pseudocholinesterase.

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The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity

Abstract

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