The effects of fetal exchange transfusion with a red blood cell substitute

Anthony Ambrose; Robert C. Cefalo; Watson A. Bowes

doi:10.1016/0002-9378(86)90627-7

The effects of fetal exchange transfusion with a red blood cell substitute

Anthony Ambrose, Robert C. Cefalo, Watson A. Bowes

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Isovolemic exchange transfusion in the fetal lamb in utero was performed with the use of Fluosol-DA (20%), a perfluorochemical erythrocyte substitute. With maternal hyperoxygenation, a physiologic Po₂ was maintained in the fetal lambs, although the total fetal oxygen content decreased as the hematocrit dropped. Because of the oxygen-carrying properties of the perfluorochemical emulsion, the fraction of fetal oxygen carried in the dissolved state increased significantly when compared with that in controls that received saline solution.

Original language	English (US)
Pages (from-to)	667-674
Number of pages	8
Journal	American journal of obstetrics and gynecology
Volume	154
Issue number	3
DOIs	https://doi.org/10.1016/0002-9378(86)90627-7
State	Published - Mar 1986

All Science Journal Classification (ASJC) codes

Obstetrics and Gynecology

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10.1016/0002-9378(86)90627-7

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title = "The effects of fetal exchange transfusion with a red blood cell substitute",

abstract = "Isovolemic exchange transfusion in the fetal lamb in utero was performed with the use of Fluosol-DA (20%), a perfluorochemical erythrocyte substitute. With maternal hyperoxygenation, a physiologic Po2 was maintained in the fetal lambs, although the total fetal oxygen content decreased as the hematocrit dropped. Because of the oxygen-carrying properties of the perfluorochemical emulsion, the fraction of fetal oxygen carried in the dissolved state increased significantly when compared with that in controls that received saline solution.",

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year = "1986",

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AU - Cefalo, Robert C.

AU - Bowes, Watson A.

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AB - Isovolemic exchange transfusion in the fetal lamb in utero was performed with the use of Fluosol-DA (20%), a perfluorochemical erythrocyte substitute. With maternal hyperoxygenation, a physiologic Po2 was maintained in the fetal lambs, although the total fetal oxygen content decreased as the hematocrit dropped. Because of the oxygen-carrying properties of the perfluorochemical emulsion, the fraction of fetal oxygen carried in the dissolved state increased significantly when compared with that in controls that received saline solution.

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ER -

The effects of fetal exchange transfusion with a red blood cell substitute

Abstract

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