The effects of high- and low-dose aspirin on thermoregulation during and after acute cold exposure

Leigh K. Murray, Ronald Otterstetter, Matthew D. Muller, Ellen L. Glickman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: To explore the effect of aspirin on the thermoregulatory responses of men during exposure to 12°C air (acute cold exposure) for a period of 120 minutes and recovery in 25°C air (rewarming) for 120 minutes. Methods: Seven male subjects (26.1 ± 2.4 yr) underwent pre-experimental testing to determine peak VO2 and body composition. Participants underwent 3 trials in which they ingested the following for 1 week prior to each experimental trial: a capsule filled with cellulose (placebo), 81 mg · day-1 of aspirin (low-dose aspirin), or 650 mg · day -1 of aspirin (high-dose aspirin). Each trial consisted of a 30-minute baseline period, 120 minutes of exposure to 12°C air, and 120 minutes of recovery in 25°C air. Mean skin temperature and rectal temperature (Tre) were measured, and heat production was calculated. Results: During both acute cold exposure and rewarming, analysis of variance revealed a main effect for time (P <.05) with respect to Tre, mean skin temperature, and heat production. However, there were no significant differences between the treatments or treatment by time interactions. Conclusions: These data demonstrate that aspirin had no significant effect on the thermal and metabolic responses during acute cold exposure and rewarming.

Original languageEnglish (US)
Pages (from-to)321-325
Number of pages5
JournalWilderness and Environmental Medicine
Issue number4
StatePublished - Dec 2011

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Public Health, Environmental and Occupational Health


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