TY - JOUR
T1 - The effects of high- and low-dose aspirin on thermoregulation during and after acute cold exposure
AU - Murray, Leigh K.
AU - Otterstetter, Ronald
AU - Muller, Matthew D.
AU - Glickman, Ellen L.
N1 - Funding Information:
This investigation was supported by a grant from Research and Graduate Studies at Kent State University . The authors wish to thank Anne Muller for her assistance in preparing the figures.
PY - 2011/12
Y1 - 2011/12
N2 - Objective: To explore the effect of aspirin on the thermoregulatory responses of men during exposure to 12°C air (acute cold exposure) for a period of 120 minutes and recovery in 25°C air (rewarming) for 120 minutes. Methods: Seven male subjects (26.1 ± 2.4 yr) underwent pre-experimental testing to determine peak VO2 and body composition. Participants underwent 3 trials in which they ingested the following for 1 week prior to each experimental trial: a capsule filled with cellulose (placebo), 81 mg · day-1 of aspirin (low-dose aspirin), or 650 mg · day -1 of aspirin (high-dose aspirin). Each trial consisted of a 30-minute baseline period, 120 minutes of exposure to 12°C air, and 120 minutes of recovery in 25°C air. Mean skin temperature and rectal temperature (Tre) were measured, and heat production was calculated. Results: During both acute cold exposure and rewarming, analysis of variance revealed a main effect for time (P <.05) with respect to Tre, mean skin temperature, and heat production. However, there were no significant differences between the treatments or treatment by time interactions. Conclusions: These data demonstrate that aspirin had no significant effect on the thermal and metabolic responses during acute cold exposure and rewarming.
AB - Objective: To explore the effect of aspirin on the thermoregulatory responses of men during exposure to 12°C air (acute cold exposure) for a period of 120 minutes and recovery in 25°C air (rewarming) for 120 minutes. Methods: Seven male subjects (26.1 ± 2.4 yr) underwent pre-experimental testing to determine peak VO2 and body composition. Participants underwent 3 trials in which they ingested the following for 1 week prior to each experimental trial: a capsule filled with cellulose (placebo), 81 mg · day-1 of aspirin (low-dose aspirin), or 650 mg · day -1 of aspirin (high-dose aspirin). Each trial consisted of a 30-minute baseline period, 120 minutes of exposure to 12°C air, and 120 minutes of recovery in 25°C air. Mean skin temperature and rectal temperature (Tre) were measured, and heat production was calculated. Results: During both acute cold exposure and rewarming, analysis of variance revealed a main effect for time (P <.05) with respect to Tre, mean skin temperature, and heat production. However, there were no significant differences between the treatments or treatment by time interactions. Conclusions: These data demonstrate that aspirin had no significant effect on the thermal and metabolic responses during acute cold exposure and rewarming.
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U2 - 10.1016/j.wem.2011.06.007
DO - 10.1016/j.wem.2011.06.007
M3 - Article
C2 - 21907600
AN - SCOPUS:82755197763
SN - 1080-6032
VL - 22
SP - 321
EP - 325
JO - Wilderness and Environmental Medicine
JF - Wilderness and Environmental Medicine
IS - 4
ER -
