The efficacy of human atrial natriuretic peptide in patients with renal dysfunction undergoing cardiac surgery

Kenta Izumi, Kiyoyuki Eishi, Shiro Yamachika, Kouji Hashizume, Seiichi Tada, Kentaro Yamane, Hideaki Takai, Kazuyoshi Tanigawa, Takashi Miura, Shun Nakaji

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objectives: The purpose of this study was to investigate the efficacy of carperitide (human atrial natriuretic peptide [h-ANP]) in perioperative management in patients with renal dysfunction, especially its kidney-protecting effects. Patients and Methods: The subjects were 18 patients who underwent elective cardiac surgery using cardiopulmonary bypass (CPB) with a preoperative serum creatinine (Cr) level of 1.2 mg/dl or more. The subjects were prospectively assigned to 2 groups: an h-ANPtreated group (Group H, n = 10) and a non-h-ANP-treated group (Group N, n = 8). At the beginning of surgery, h-ANP administration was initiated and continued for 5 days or more. The central dose was 0.02 μ;/kg/min. The primary end point included the serum Cr level and creatinine clearance (Ccr). Results: In Group H, Cr level significantly decreased after surgery compared to the preoperative level. The Ccr values were significantly higher 2 and 3 days after surgery than the preoperative values. And the intraoperative urine volume significantly increased. In Group H, an increase in urinary N-acetyl-beta-D-glucosaminidase (NAG) level the day after surgery was significantly inhibited in comparison with Group N. Conclusion: The results of this study suggest that in patients with renal dysfunction before cardiac surgery, continuous low-dose h-ANP therapy maintains renal function, preventing its deterioration. (Ann Thorac Cardiovasc Surg 2008; 14: 294-302).

Original languageEnglish (US)
Pages (from-to)294-302
Number of pages9
JournalAnnals of Thoracic and Cardiovascular Surgery
Issue number5
StatePublished - Oct 2008

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Gastroenterology


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