Abstract
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 153-182 |
| Number of pages | 30 |
| Journal | Brain Imaging and Behavior |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2014 |
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Neurology
- Cognitive Neuroscience
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Behavioral Neuroscience
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In: Brain Imaging and Behavior, Vol. 8, No. 2, 06.2014, p. 153-182.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - The ENIGMA Consortium
T2 - Large-scale collaborative analyses of neuroimaging and genetic data
AU - Thompson, Paul M.
AU - Stein, Jason L.
AU - Medland, Sarah E.
AU - Hibar, Derrek P.
AU - Vasquez, Alejandro Arias
AU - Renteria, Miguel E.
AU - Toro, Roberto
AU - Jahanshad, Neda
AU - Schumann, Gunter
AU - Franke, Barbara
AU - Wright, Margaret J.
AU - Martin, Nicholas G.
AU - Agartz, Ingrid
AU - Alda, Martin
AU - Alhusaini, Saud
AU - Almasy, Laura
AU - Almeida, Jorge
AU - Alpert, Kathryn
AU - Andreasen, Nancy C.
AU - Andreassen, Ole A.
AU - Apostolova, Liana G.
AU - Appel, Katja
AU - Armstrong, Nicola J.
AU - Aribisala, Benjamin
AU - Bastin, Mark E.
AU - Bauer, Michael
AU - Bearden, Carrie E.
AU - Bergmann, Ørjan
AU - Binder, Elisabeth B.
AU - Blangero, John
AU - Bockholt, Henry J.
AU - Bøen, Erlend
AU - Bois, Catherine
AU - Boomsma, Dorret I.
AU - Booth, Tom
AU - Bowman, Ian J.
AU - Bralten, Janita
AU - Brouwer, Rachel M.
AU - Brunner, Han G.
AU - Brohawn, David G.
AU - Buckner, Randy L.
AU - Buitelaar, Jan
AU - Bulayeva, Kazima
AU - Bustillo, Juan R.
AU - Calhoun, Vince D.
AU - Cannon, Dara M.
AU - Cantor, Rita M.
AU - Carless, Melanie A.
AU - Caseras, Xavier
AU - Cavalleri, Gianpiero L.
AU - Chakravarty, M. Mallar
AU - Chang, Kiki D.
AU - Ching, Christopher R.K.
AU - Christoforou, Andrea
AU - Cichon, Sven
AU - Clark, Vincent P.
AU - Conrod, Patricia
AU - Coppola, Giovanni
AU - Crespo-Facorro, Benedicto
AU - Curran, Joanne E.
AU - Czisch, Michael
AU - Deary, Ian J.
AU - de Geus, Eco J.C.
AU - den Braber, Anouk
AU - Delvecchio, Giuseppe
AU - Depondt, Chantal
AU - de Haan, Lieuwe
AU - de Zubicaray, Greig I.
AU - Dima, Danai
AU - Dimitrova, Rali
AU - Djurovic, Srdjan
AU - Dong, Hongwei
AU - Donohoe, Gary
AU - Duggirala, Ravindranath
AU - Dyer, Thomas D.
AU - Ehrlich, Stefan
AU - Ekman, Carl Johan
AU - Elvsåshagen, Torbjørn
AU - Emsell, Louise
AU - Erk, Susanne
AU - Espeseth, Thomas
AU - Fagerness, Jesen
AU - Fears, Scott
AU - Fedko, Iryna
AU - Fernández, Guillén
AU - Fisher, Simon E.
AU - Foroud, Tatiana
AU - Fox, Peter T.
AU - Francks, Clyde
AU - Frangou, Sophia
AU - Frey, Eva Maria
AU - Frodl, Thomas
AU - Frouin, Vincent
AU - Garavan, Hugh
AU - Giddaluru, Sudheer
AU - Glahn, David C.
AU - Godlewska, Beata
AU - Goldstein, Rita Z.
AU - Gollub, Randy L.
AU - Grabe, Hans J.
AU - Grimm, Oliver
AU - Gruber, Oliver
AU - Guadalupe, Tulio
AU - Gur, Raquel E.
AU - Gur, Ruben C.
AU - Göring, Harald H.H.
AU - Hagenaars, Saskia
AU - Hajek, Tomas
AU - Hall, Geoffrey B.
AU - Hall, Jeremy
AU - Hardy, John
AU - Hartman, Catharina A.
AU - Hass, Johanna
AU - Hatton, Sean N.
AU - Haukvik, Unn K.
AU - Hegenscheid, Katrin
AU - Heinz, Andreas
AU - Hickie, Ian B.
AU - Ho, Beng Choon
AU - Hoehn, David
AU - Hoekstra, Pieter J.
AU - Hollinshead, Marisa
AU - Holmes, Avram J.
AU - Homuth, Georg
AU - Hoogman, Martine
AU - Hong, L. Elliot
AU - Hosten, Norbert
AU - Hottenga, Jouke Jan
AU - Hulshoff Pol, Hilleke E.
AU - Hwang, Kristy S.
AU - Jack, Clifford R.
AU - Jenkinson, Mark
AU - Johnston, Caroline
AU - Jönsson, Erik G.
AU - Kahn, René S.
AU - Kasperaviciute, Dalia
AU - Kelly, Sinead
AU - Kim, Sungeun
AU - Kochunov, Peter
AU - Koenders, Laura
AU - Krämer, Bernd
AU - Kwok, John B.J.
AU - Lagopoulos, Jim
AU - Laje, Gonzalo
AU - Landen, Mikael
AU - Landman, Bennett A.
AU - Lauriello, John
AU - Lawrie, Stephen M.
AU - Lee, Phil H.
AU - Le Hellard, Stephanie
AU - Lemaître, Herve
AU - Leonardo, Cassandra D.
AU - Li, Chiang shan
AU - Liberg, Benny
AU - Liewald, David C.
AU - Liu, Xinmin
AU - Lopez, Lorna M.
AU - Loth, Eva
AU - Lourdusamy, Anbarasu
AU - Luciano, Michelle
AU - Macciardi, Fabio
AU - Machielsen, Marise W.J.
AU - MacQueen, Glenda M.
AU - Malt, Ulrik F.
AU - Mandl, René
AU - Manoach, Dara S.
AU - Martinot, Jean Luc
AU - Matarin, Mar
AU - Mather, Karen A.
AU - Mattheisen, Manuel
AU - Mattingsdal, Morten
AU - Meyer-Lindenberg, Andreas
AU - McDonald, Colm
AU - McIntosh, Andrew M.
AU - McMahon, Francis J.
AU - McMahon, Katie L.
AU - Meisenzahl, Eva
AU - Melle, Ingrid
AU - Milaneschi, Yuri
AU - Mohnke, Sebastian
AU - Montgomery, Grant W.
AU - Morris, Derek W.
AU - Moses, Eric K.
AU - Mueller, Bryon A.
AU - Muñoz Maniega, Susana
AU - Mühleisen, Thomas W.
AU - Müller-Myhsok, Bertram
AU - Mwangi, Benson
AU - Nauck, Matthias
AU - Nho, Kwangsik
AU - Nichols, Thomas E.
AU - Nilsson, Lars Göran
AU - Nugent, Allison C.
AU - Nyberg, Lars
AU - Olvera, Rene L.
AU - Oosterlaan, Jaap
AU - Ophoff, Roel A.
AU - Pandolfo, Massimo
AU - Papalampropoulou-Tsiridou, Melina
AU - Papmeyer, Martina
AU - Paus, Tomas
AU - Pausova, Zdenka
AU - Pearlson, Godfrey D.
AU - Penninx, Brenda W.
AU - Peterson, Charles P.
AU - Pfennig, Andrea
AU - Phillips, Mary
AU - Pike, G. Bruce
AU - Poline, Jean Baptiste
AU - Potkin, Steven G.
AU - Pütz, Benno
AU - Ramasamy, Adaikalavan
AU - Rasmussen, Jerod
AU - Rietschel, Marcella
AU - Rijpkema, Mark
AU - Risacher, Shannon L.
AU - Roffman, Joshua L.
AU - Roiz-Santiañez, Roberto
AU - Romanczuk-Seiferth, Nina
AU - Rose, Emma J.
AU - Royle, Natalie A.
AU - Rujescu, Dan
AU - Ryten, Mina
AU - Sachdev, Perminder S.
AU - Salami, Alireza
AU - Satterthwaite, Theodore D.
AU - Savitz, Jonathan
AU - Saykin, Andrew J.
AU - Scanlon, Cathy
AU - Schmaal, Lianne
AU - Schnack, Hugo G.
AU - Schork, Andrew J.
AU - Schulz, S. Charles
AU - Schür, Remmelt
AU - Seidman, Larry
AU - Shen, Li
AU - Shoemaker, Jody M.
AU - Simmons, Andrew
AU - Sisodiya, Sanjay M.
AU - Smith, Colin
AU - Smoller, Jordan W.
AU - Soares, Jair C.
AU - Sponheim, Scott R.
AU - Sprooten, Emma
AU - Starr, John M.
AU - Steen, Vidar M.
AU - Strakowski, Stephen
AU - Strike, Lachlan
AU - Sussmann, Jessika
AU - Sämann, Philipp G.
AU - Teumer, Alexander
AU - Toga, Arthur W.
AU - Tordesillas-Gutierrez, Diana
AU - Trabzuni, Daniah
AU - Trost, Sarah
AU - Turner, Jessica
AU - Van den Heuvel, Martijn
AU - van der Wee, Nic J.
AU - van Eijk, Kristel
AU - van Erp, Theo G.M.
AU - van Haren, Neeltje E.M.
AU - van 't Ent, Dennis
AU - van Tol, Marie Jose
AU - Valdés Hernández, Maria C.
AU - Veltman, Dick J.
AU - Versace, Amelia
AU - Völzke, Henry
AU - Walker, Robert
AU - Walter, Henrik
AU - Wang, Lei
AU - Wardlaw, Joanna M.
AU - Weale, Michael E.
AU - Weiner, Michael W.
AU - Wen, Wei
AU - Westlye, Lars T.
AU - Whalley, Heather C.
AU - Whelan, Christopher D.
AU - White, Tonya
AU - Winkler, Anderson M.
AU - Wittfeld, Katharina
AU - Woldehawariat, Girma
AU - Wolf, Christiane
AU - Zilles, David
AU - Zwiers, Marcel P.
AU - Thalamuthu, Anbupalam
AU - Schofield, Peter R.
AU - Freimer, Nelson B.
AU - Lawrence, Natalia S.
AU - Drevets, Wayne
N1 - Funding Information: This article reviews work published by the ENIGMA Consortium and its Working Groups (http://enigma.ini.usc.edu). It was written collaboratively; P.T. wrote the first draft and all listed authors revised and edited the document for important intellectual content, using Google Docs for parallel editing, and approved it. Some ENIGMA investigators contributed to the design and implementation of ENIGMA or provided data but did not participate in the analysis or writing of this report. A complete listing of ENIGMA investigators is available at http://enigma.ini.usc.edu/publications/the-enigma-consortium-in-review/ For ADNI, some investigators contributed to the design and implementation of ADNI or provided data but did not participate in the analysis or writing of this report. A complete listing of ADNI investigators is available at http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ ADNI_Acknowledgement_List.pdf The work reviewed here was funded by a large number of federal and private agencies worldwide, listed in Stein et al. (2012); the funding for listed consortia is also itemized in Stein et al. (2012).
PY - 2014/6
Y1 - 2014/6
N2 - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
AB - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
UR - http://www.scopus.com/inward/record.url?scp=84899930958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899930958&partnerID=8YFLogxK
U2 - 10.1007/s11682-013-9269-5
DO - 10.1007/s11682-013-9269-5
M3 - Article
C2 - 24399358
AN - SCOPUS:84899930958
SN - 1931-7557
VL - 8
SP - 153
EP - 182
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 2
ER -