TY - JOUR
T1 - The Enigma of AHR Activation in the Skin
T2 - Interplay among Ligands, Metabolism, and Bioavailability
AU - van den Bogaard, Ellen H.
AU - Perdew, Gary H.
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/6
Y1 - 2021/6
N2 - AHR is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment. In addition to therapies involving active ligands such as coal tar and tapinarof, the inhibition of AHR-dependent enzymatic activities in the skin may be an alternative approach to resolving skin inflammation.
AB - AHR is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment. In addition to therapies involving active ligands such as coal tar and tapinarof, the inhibition of AHR-dependent enzymatic activities in the skin may be an alternative approach to resolving skin inflammation.
UR - https://www.scopus.com/pages/publications/85106389671
UR - https://www.scopus.com/pages/publications/85106389671#tab=citedBy
U2 - 10.1016/j.jid.2020.12.013
DO - 10.1016/j.jid.2020.12.013
M3 - Comment/debate
C2 - 34024340
AN - SCOPUS:85106389671
SN - 0022-202X
VL - 141
SP - 1385
EP - 1388
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 6
ER -