The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability

Ellen H. van den Bogaard; Gary H. Perdew

doi:10.1016/j.jid.2020.12.013

The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability

Ellen H. van den Bogaard
, Gary H. Perdew

Research output: Contribution to journal › Comment/debate › peer-review

18 Scopus citations

Abstract

AHR is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment. In addition to therapies involving active ligands such as coal tar and tapinarof, the inhibition of AHR-dependent enzymatic activities in the skin may be an alternative approach to resolving skin inflammation.

Original language	English (US)
Pages (from-to)	1385-1388
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	141
Issue number	6
DOIs	https://doi.org/10.1016/j.jid.2020.12.013
State	Published - Jun 2021

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2020.12.013

Cite this

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title = "The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability",

abstract = "AHR is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment. In addition to therapies involving active ligands such as coal tar and tapinarof, the inhibition of AHR-dependent enzymatic activities in the skin may be an alternative approach to resolving skin inflammation.",

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AU - Perdew, Gary H.

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AB - AHR is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment. In addition to therapies involving active ligands such as coal tar and tapinarof, the inhibition of AHR-dependent enzymatic activities in the skin may be an alternative approach to resolving skin inflammation.

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DO - 10.1016/j.jid.2020.12.013

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ER -

The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability

Abstract

All Science Journal Classification (ASJC) codes

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