TY - JOUR
T1 - The epigenetics of gastrointestinal malignancies
AU - Hasanali, Zainul
AU - Stuart, August
AU - Yee, Nelson
AU - Sharma, Kamal
AU - Epner, Elliot
N1 - Funding Information:
E. Epner is supported by grants from Merck and
PY - 2012/12
Y1 - 2012/12
N2 - Gastrointestinal malignancies, including colorectal cancer (CRC), pancreatic cancer, and esophageal cancer, have been classically seen as genetic diseases, involving mutations and/or deletions in oncogenes and tumor suppressor genes. Recent evidence demonstrates that epigenetic changes coexist with these genetic changes and contribute to the malignant phenotype. This review will focus on epigenetic dysregulation in gastrointestinal malignancies involving multiple mechanisms of epigenetic control. Interactions between studied epigenetic alterations and genetic alterations are common.
AB - Gastrointestinal malignancies, including colorectal cancer (CRC), pancreatic cancer, and esophageal cancer, have been classically seen as genetic diseases, involving mutations and/or deletions in oncogenes and tumor suppressor genes. Recent evidence demonstrates that epigenetic changes coexist with these genetic changes and contribute to the malignant phenotype. This review will focus on epigenetic dysregulation in gastrointestinal malignancies involving multiple mechanisms of epigenetic control. Interactions between studied epigenetic alterations and genetic alterations are common.
UR - http://www.scopus.com/inward/record.url?scp=84869103854&partnerID=8YFLogxK
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U2 - 10.1007/s11888-012-0147-0
DO - 10.1007/s11888-012-0147-0
M3 - Review article
AN - SCOPUS:84869103854
SN - 1556-3790
VL - 8
SP - 254
EP - 262
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
IS - 4
ER -