Abstract
Gastrointestinal malignancies, including colorectal cancer (CRC), pancreatic cancer, and esophageal cancer, have been classically seen as genetic diseases, involving mutations and/or deletions in oncogenes and tumor suppressor genes. Recent evidence demonstrates that epigenetic changes coexist with these genetic changes and contribute to the malignant phenotype. This review will focus on epigenetic dysregulation in gastrointestinal malignancies involving multiple mechanisms of epigenetic control. Interactions between studied epigenetic alterations and genetic alterations are common.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 254-262 |
| Number of pages | 9 |
| Journal | Current Colorectal Cancer Reports |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Hepatology
- Oncology
- Gastroenterology
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