The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Kunihisa Nakai; Shin Mineishi; Masahiro Kami; Yoshinobu Konda; Ryuji Tanosaki; Yoichi Takaue

The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Kunihisa Nakai, Shin Mineishi, Masahiro Kami, Yoshinobu Konda, Ryuji Tanosaki, Yoichi Takaue

Research output: Contribution to journal › Article › peer-review

Abstract

It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.

Original language	English (US)
Pages (from-to)	115-117
Number of pages	3
Journal	Haematologica
Volume	88
Issue number	1
State	Published - Feb 1 2003

All Science Journal Classification (ASJC) codes

Hematology

Cite this

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abstract = "It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.",

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AU - Konda, Yoshinobu

AU - Tanosaki, Ryuji

AU - Takaue, Yoichi

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AB - It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimenrelated toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.

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The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Abstract

All Science Journal Classification (ASJC) codes

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